Effects of iron intake on iron stores in elderly men and women: Longitudinal and cross-sectional results
Effects of iron intake on iron stores in elderly men and women: Longitudinal and cross-sectional results
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DOI：
10.1080/07315724.2000.10718925
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发表时间：
2000-04-01
影响因子：
3.5
通讯作者：
Baumgartner, RN
中科院分区：
文献类型：
--
作者：
Garry, PJ;Hunt, WC;Baumgartner, RN
目的：对于中年和老年受试者，存在铁摄入量增加的问题，特别是与红肉消费相关的血红素铁，导致铁储存增加，从而导致葡萄糖稳态紊乱和心血管疾病和某些类型癌症的风险。本研究的目的是调查血红素，非血红素和铁补充剂对健康老年男性和女性的铁储存的影响。方法：我们进行了为期10年的纵向研究（48名男性和77名女性）和一年的横断面研究（165名男性和226名女性）在健康老年男性和女性参加的新墨西哥州老化过程研究。Tron商店估计血清铁蛋白浓度和铁的摄入量是由三天的食物记录在纵向研究和食品频率问卷在横断面study.Results：我们发现血红素铁的摄入量和铁商店之间没有关联的纵向或横断面研究。在横断面研究中，我们发现在妇女中，但不是在男性，年龄和补充铁的摄入量显着和正相关增加铁stores.Conclusion：铁存储在老年男性被认为是达到稳定状态的水平，铁吸收调整到一个水平，刚好足以覆盖基础铁损失。在老年妇女中，我们推测绝经后妇女没有足够的时间达到铁立体的稳态水平，导致铁吸收随年龄增加。另一个因素是，由于持续的月经失血，使用激素替代疗法可能会进一步延迟一些女性达到稳定状态的铁水平。
Objective: For middle aged and elderly subjects there is a concern that increased iron intake, especially heme iron associated with consumption of red meat, leads to increased iron stores resulting in disturbed glucose homeostasis and risk for cardiovascular disease and certain types of cancer. The aim of this study was to investigate me influence of heme, non-heme and iron supplementation on iron stores in healthy elderly men and women.Method: We conducted a 10 year longitudinal study (48 men and 77 women) and a one year cross-sectional study (165 men and 226 women) in healthy elderly men and women enrolled in the New Mexico Aging process Study. Tron stores were estimated by serum ferritin concentrations and iron intake was determined by three-day food records in the longitudinal study and by a food frequency questionnaire in the cross-sectional study.Results: We found no association between heme iron intake and iron stores in either the longitudinal or cross sectional study. In the cross-sectional study we found in women, but not in men, that age and supplemental iron intake were significantly and positively associated with increased iron stores.Conclusion: Iron stores in elderly men are thought to reach steady state levels where iron absorption is adjusted to a level just sufficient to cover basal iron losses. In elderly women, we speculate that not enough time has elapsed for postmenopausal women to reach steady state levels of iron stereo resulting in increases in iron absorption with age. Another factor is that use of hormone replacement therapy could further delay some women in reaching steady state iron levels due to continued menstrual blood losses.