Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention.
Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention.
复制标题
DOI：
10.1097/grf.0000000000000312
复制
发表时间：
2017-12
影响因子：
1.5
通讯作者：
Cho KR
中科院分区：
文献类型：
--
作者：
Karnezis AN;Cho KR
用于卵巢癌发病机制和预防建模的临床前模型相对未得到充分利用且资金不足。一些评论详细介绍了众多已发表的卵巢癌模型。在这篇综述中，我们将概述实验模型系统、它们的优点和局限性，并使用选定的模型来说明如何使用它们来解决有关卵巢癌发病机制的具体问题。然后，我们将重点介绍迄今为止进行的一些临床前预防研究，并讨论解决有关卵巢癌预防策略的重要未解答问题所需的实验。
Preclinical models are relatively underutilized and underfunded resources for modeling the pathogenesis and prevention of ovarian cancers. Several reviews have detailed the numerous published models of ovarian cancer. In this review, we will provide an overview of experimental model systems, their strengths and limitations, and use selected models to illustrate how they can be used to address specific issues about ovarian cancer pathogenesis. We will then highlight some of the preclinical prevention studies performed to date and discuss experiments needed to address important unanswered questions about ovarian cancer prevention strategies.