Poly(oligonucleotide)
Poly(oligonucleotide)
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DOI：
10.1021/ja503142s
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发表时间：
2014-08-13
影响因子：
15
通讯作者：
Gianneschi, Nathan C.
中科院分区：
文献类型：
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作者：
James, Carrie R.;Rush, Anthony M.;Gianneschi, Nathan C.
本文报道了以核酸单体为原料，通过接枝聚合法制备聚（寡核苷酸）刷状聚合物和两亲性刷状共聚物。我们描述了以(IMesH(2))-(C5H5N)(2)(Cl)（2)RuCHPh为引发剂，通过开环复分解聚合（ROMP），聚合pna -降冰片基单体得到聚pna（多肽核酸））。(1)此外，我们提出了用两亲性嵌段共聚物制备聚pna纳米粒子，并描述了它们与互补单链DNA （ssDNA）寡核苷酸的杂交。
Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH(2))-(C5H5N)(2)(Cl)(2)RuCHPh.(1) In addition, we present the preparation of poly-PNA nanopartides from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.