Gait speed or gait variability, which one to use as a marker of risk to develop Alzheimer disease? A pilot study
Gait speed or gait variability, which one to use as a marker of risk to develop Alzheimer disease? A pilot study
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DOI：
10.1007/s40520-015-0392-6
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Petermans, J.
中科院分区：
文献类型：
--
作者：
Gillain, S.;Drame, M.;Petermans, J.
以往的文献表明，步态分析的兴趣，以预测老年人的认知能力下降。这项初步研究的目的是确定，如果步态速度或步态变异性是一个标志物，能够早期识别，轻度认知障碍（MCI）的科目，那些在未来发展为阿尔茨海默氏病（AD）的风险。13 MCI科目包括在2007年。在2007年和2008年，使用三轴加速度计（LocomeanTM（A（R）在简单任务（ST）和双重任务（DT）中测量了他们的步态参数（步行速度、步长和步态频率、规则性和对称性）。在2007年纳入的13名MCI受试者中，2008年评估了10名。因此，收集了23次（2007年13次+2008年10次）步态测试。2011年，MCI患者在发生AD（基线和2011年之间）时被视为“MCI+”，如果没有发生，则被视为“MCI-aEuroe”。在23次步态测试中，15次来自MCI+（2007年9次步态测试，2008年6次），8次来自MCI-（2007年4次步态测试，2008年4次步态测试）。采用Mann-Whitney非参数U检验比较MCI+和MCI-患者的步态参数，MCI+患者的步态速度、对称性和规律性均低于MCI-患者。作者讨论了这项工作的不足和优势，这些结果表明，步态速度和步态变异性可以作为早期识别MCI发展为AD的风险的标志。
Previous literature demonstrates the interest of gait analysis to predict cognitive decline in old people.This pilot study aims to determine if gait speed or gait variability is a marker able to early identify, among mild cognitive impairment (MCI) subjects, those at risk to develop Alzheimer's disease (AD) in the future.13 MCI subjects were included in 2007. Their gait parameters (walking speed, stride length and gait frequency, regularity and symmetry) were measured in 2007 and 2008 in simple task (ST) and in dual task (DT) using a triaxial accelerometer (Locometrix(A (R))). Among the 13 MCI subjects included in 2007, 10 were assessed in 2008. So, 23 (13 in 2007 + 10 in 2008) gait tests were collected. In 2011, MCI people were considered as "MCI+" when they developed AD (between baseline and 2011) and as "MCI-aEuroe if they did not. Among the 23 gait tests, 15 were from MCI+ (9 gait tests in 2007 and 6 in 2008) and 8 from MCI- (4 gait tests in 2007 and 4 gait tests in 2008). Mann-Whitney non-parametric U test was used to compare gait parameters of MCI+ and MCI-.Gait speed, symmetry and regularity were lower in MCI+ than in MCI-.Despite the small sample size, the results presented in this original pilot study are in line as the infrequent previous literature related to this topic. The authors discuss lacks and strengths of this work.These results suggest that both gait speed and gait variability could be markers to early identify MCI at risk to develop AD.