Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits.
Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits.
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DOI：
10.3389/fphys.2021.624595
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发表时间：
2021
影响因子：
4
通讯作者：
Boychuk CR
中科院分区：
文献类型：
--
作者：
Espinoza L;Fedorchak S;Boychuk CR
有共识认为，心脏受副交感神经系统和交感神经系统的支配。然而，副交感神经系统在控制心脏功能中的作用受到的关注明显少于交感神经系统。新的神经调节策略重新引起了人们对副交感神经（或迷走神经）运动输出治疗心血管疾病和心脏功能不良的潜力的兴趣。这种新的兴趣强调了更好地了解迷走神经运动输出是如何产生和调节的关键需要。尽管副交感神经系统在调节胃肠道功能和能量稳态中具有经典作用，但心血管疾病和代谢疾病之间存在明确的临床联系，解决这一知识空白对于我们理解代谢线索和迷走神经运动输出之间的相互作用至关重要。因此，本文着重介绍了中枢迷走神经回路参与感知代谢状态和制定迷走神经运动输出影响心脏功能。它将回顾我们目前对脑干迷走神经回路的理解，以及它们在整合代谢信号到心脏活动中的独特地位。这将包括一个概述，不仅如何代谢线索改变迷走神经脑干电路，而且迷走神经运动输出可能会影响整体的全身浓度的代谢线索已知的心脏组织。总之，这篇综述提出迷走神经脑干回路提供了一个整合的网络，能够调节和响应代谢线索，以控制心脏功能。
There is consensus that the heart is innervated by both the parasympathetic and sympathetic nervous system. However, the role of the parasympathetic nervous system in controlling cardiac function has received significantly less attention than the sympathetic nervous system. New neuromodulatory strategies have renewed interest in the potential of parasympathetic (or vagal) motor output to treat cardiovascular disease and poor cardiac function. This renewed interest emphasizes a critical need to better understand how vagal motor output is generated and regulated. With clear clinical links between cardiovascular and metabolic diseases, addressing this gap in knowledge is undeniably critical to our understanding of the interaction between metabolic cues and vagal motor output, notwithstanding the classical role of the parasympathetic nervous system in regulating gastrointestinal function and energy homeostasis. For this reason, this review focuses on the central, vagal circuits involved in sensing metabolic state(s) and enacting vagal motor output to influence cardiac function. It will review our current understanding of brainstem vagal circuits and their unique position to integrate metabolic signaling into cardiac activity. This will include an overview of not only how metabolic cues alter vagal brainstem circuits, but also how vagal motor output might influence overall systemic concentrations of metabolic cues known to act on the cardiac tissue. Overall, this review proposes that the vagal brainstem circuits provide an integrative network capable of regulating and responding to metabolic cues to control cardiac function.
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DOI：
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影响因子：
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作者：
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