Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties☆
Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties☆
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DOI：
10.1016/j.addr.2017.10.001
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发表时间：
2017-10
影响因子：
16.1
通讯作者：
Lei-Lei Wu-Lei;Wei Shan;Zhirong Zhang;Yuan Huang
中科院分区：
文献类型：
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作者：
Lei-Lei Wu-Lei;Wei Shan;Zhirong Zhang;Yuan Huang
尽管近年来已经研究了纳米技术以增加粘膜给药药物的生物利用度和治疗效果，但是许多障碍（例如，pH环境、酶和粘液）仍然限制递送效率。同时，上皮细胞也会影响药物的全身粘膜释放。在所有的屏障中，保护性粘液引起了越来越多的关注，它强烈地阻碍了纳米载体对上皮的可及性。因此，已经设计了使用两种有争议的策略来克服粘液屏障的试验：粘膜粘附和粘液渗透。本文综述了粘液层对纳米材料的影响，并介绍了通过调节表面性质（即，亲水性/疏水性和表面电荷）以克服粘液屏障。此外，它还审查了先进的修饰方法，以满足纳米载体的不同表面要求，以克服全身粘膜递送中的粘液和上皮屏障。
Although nanotechnology has been investigated during recent years to increase the bioavailability and therapeutic effects of mucosal administrated drugs, numerous barriers (e.g., pH environment, enzymes and mucus) still limit the delivery efficiency. And the epithelium would also affect the systemic mucosal drug delivery. Amongst all the barriers, the protective mucus has drawn more and more attention, which strongly hinders the accessibility of nanovehicles to epithelium. Therefore, trials to conquer the mucus barrier have been designed using two controversial strategies: mucoadhesion and mucus-penetration. This review summarizes the influence of mucus layer on nanomaterials and introduces the modification strategies by modulating surface properties (i.e., hydrophilicity/hydrophobicity and surface charge) to overcome mucus barriers. Furthermore, it also reviews advanced modification methods to meet the different surface requirements of nanovehicles to overcome mucus and epithelium barriers in systemic mucosal delivery.