Corpus callosum morphometrics in young children with autism spectrum disorder
Corpus callosum morphometrics in young children with autism spectrum disorder
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DOI：
10.1007/s10803-006-0121-2
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发表时间：
2006-08-01
影响因子：
3.9
通讯作者：
Dager, Stephen R.
中科院分区：
文献类型：
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作者：
Boger-Megiddo, Inbal;Shaw, Dennis W. W.;Dager, Stephen R.
本研究评估了3-4奥尔兹自闭症谱系障碍（ASD）儿童与正常发育（TD）和发育迟缓（DD）儿童的胼胝体中矢状面横截面积。虽然与TD相比在绝对大小上没有不同，但ASD胼胝体不成比例地小，因为ASD大脑体积增加。ASD临床亚组分析显示，在更严重的影响自闭症（AD）比广泛性发育障碍，未另行说明（PDD-NOS）的儿童胼胝体减少的比例更大。DD儿童的绝对胼胝体小于ASD和TD。分区分析显示广泛分布的胼胝体ASD和TD儿童之间的差异。结果可以反映由于ASD中胼胝体中较少代表的组织增加而导致的半球间连接性降低或大脑扩大。
This study assessed midsagittal corpus callosum cross sectional areas in 3-4 year olds with autism spectrum disorder (ASD) compared to typically developing (TD) and developmentally delayed (DD) children. Though not different in absolute size compared to TD, ASD callosums were disproportionately small adjusted for increased ASD cerebral volume. ASD clinical subgroup analysis revealed greater proportional callosum reduction in the more severely affected autistic disorder (AD) than in pervasive developmental disorder-not otherwise specified (PDD-NOS) children. DD children had smaller absolute callosums than ASD and TD. Subregion analysis revealed widely distributed callosum differences between ASD and TD children. Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD.