The hippocampus supports deliberation during value-based decisions
The hippocampus supports deliberation during value-based decisions
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DOI：
10.7554/elife.46080
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发表时间：
2019-07-03
期刊：
影响因子：
7.7
通讯作者：
Shohamy, Daphna
中科院分区：
文献类型：
--
作者：
Bakkour, Akram;Palombo, Daniela J.;Shohamy, Daphna
在两个项目之间进行选择涉及对每个项目的特征及其价值的审议和比较。当在具有类似价值的选项之间进行选择时，这样的决定需要更多的时间，可能是因为这些决定需要更多的证据，但所涉及的机制尚不清楚。我们认为，海马支持审议的价值，鉴于其众所周知的作用，在展望和关系认知。我们在两个实验中评估了海马体在审议中的作用。首先，通过对健康参与者进行功能磁共振成像，我们发现海马体中的BOLD活动随着思考时间的增加而增加。第二，我们发现海马损伤的患者比对照组表现出更多的随机选择和更长的反应时间，这可能是由于他们在审议过程中未能构建基于价值或内部证据。这两组结果在基于价值的决策中比感知决策更强。
Choosing between two items involves deliberation and comparison of the features of each item and its value. Such decisions take more time when choosing between options of similar value, possibly because these decisions require more evidence, but the mechanisms involved are not clear. We propose that the hippocampus supports deliberation about value, given its well-known role in prospection and relational cognition. We assessed the role of the hippocampus in deliberation in two experiments. First, using fMRI in healthy participants, we found that BOLD activity in the hippocampus increased as a function of deliberation time. Second, we found that patients with hippocampal damage exhibited more stochastic choices and longer reaction times than controls, possibly due to their failure to construct value-based or internal evidence during deliberation. Both sets of results were stronger in value-based decisions compared to perceptual decisions.