Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus.
Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus.
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DOI：
10.7554/elife.64893
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发表时间：
2021-09-14
期刊：
影响因子：
7.7
通讯作者：
Kiani R
中科院分区：
文献类型：
--
作者：
London D;Fazl A;Katlowitz K;Soula M;Pourfar MH;Mogilner AY;Kiani R
丘脑底核（subthalamic nucleus，简称丘脑底核）被认为通过与下游基底神经节结构的连接来全面抑制运动。当受试者保留一个未启动的行动计划时，当前的理论得到了增加的重复活动的支持，但是对这些理论的关键测试需要研究当正在进行的行动被替代时的重复反应。我们在帕金森病受试者中进行这项测试，使用一种延长的伸展任务，其中运动轨迹在动作中期发生变化。我们发现，在行动开关，相反，流行的理论，活动减少。此外，与运动抑制相关的局部场电位中的β振荡在开关期间不显示增加的功率或尖峰夹带。我们报告了一个不均匀的人口神经代码在神经网络中，一个子群体编码运动学和方向，另一个编码意想不到的动作开关。我们提出了一个精心设计的神经代码，有助于规划行动和改变计划。
The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson’s disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.