Plasma miR223 is a possible biomarker for diagnosing patients with severe atopic dermatitis
Plasma miR223 is a possible biomarker for diagnosing patients with severe atopic dermatitis
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血浆 miR223 是诊断严重特应性皮炎患者的可能生物标志物
DOI：
10.1016/j.alit.2020.07.010
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发表时间：
2021
影响因子：
6.8
通讯作者：
Katoh Norito
中科院分区：
文献类型：
--
作者：
Yasuike Risa;Tamagawa-Mineoka Risa;Nakamura Naomi;Masuda Koji;Katoh Norito
MicroRNAs(MiRNA)是由19e25个核苷酸组成的小的非编码RNA，它与特定的mRNAs结合来调节翻译或加速mRNA的降解。1最近有报道指出miRNAs与哮喘、过敏性鼻炎、特应性皮炎等过敏性疾病关系密切。2、3此外，miRNAs不仅在细胞中被发现，而且在诸如血浆、血清和尿液中也被发现。体液中的miRNAs被认为很有可能作为非侵入性的生物标志物用于疾病的检测和病情判断。AD是一种常见的慢性炎症性皮肤病，以剧烈瘙痒和反复湿疹为特征。据报道，一些miRNAs在AD患者的皮损、血清和尿液中过表达，参与了AD的发病机制。研究发现，在AD患者皮肤3和全血细胞4中miR-223表达上调。然而，关于AD患者体液中miR-223的表达以及miR-223水平与临床资料的关系尚无相关数据。在本研究中，我们检测了阿尔茨海默病患者血浆中miR-223的表达，以及血浆miR-223水平与AD严重程度或实验室数据的关系。
MicroRNAs (miRNA) are small non-coding RNAs built of 19e25 nucleotides, which bind to specific mRNAs to regulate translation or accelerate mRNA degradation. 1 Recently some reported that there exist the close relationships between miRNAs and several allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis (AD). 2, 3 In addition, miRNAs have been identified not only in cells but also in body fluids such as plasma, serum, and urine. It is thought that miRNAs in body fluids are very possible to be used as non-invasive biomarkers in detection and condition of diseases.AD is a common chronic inflammatory skin disorder characterized by intense pruritus and recurrent eczematous lesions. It has been reported that some of the miRNAs are overexpressed in skin lesions, serum, and urine of AD patients and are involved in the pathogenesis of AD. It was identified that the miR-223 expressions in AD patients' skin 3 and whole blood cells 4 were upregulated. However, there was no data about the miR-223 expressions of AD patients in body fluid and the relationship between the miR-223 levels and clinical data. In this study, we examined the miR-223 expressions in AD patients' plasma, and the relationship between plasma miR-223 levels and the severity of AD or laboratory data.