Accuracy vs. computational time: Translating aortic simulations to the clinic
Accuracy vs. computational time: Translating aortic simulations to the clinic
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DOI：
10.1016/j.jbiomech.2011.11.041
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发表时间：
2012-02-02
影响因子：
2.4
通讯作者：
Hose, D. Rodney
中科院分区：
文献类型：
--
作者：
Brown, Alistair G.;Shi, Yubing;Hose, D. Rodney
最先进的主动脉血流动力学模拟具有完整的流体-结构相互作用（FSI）和耦合OD边界条件。这样的分析不仅需要大量的计算资源，而且需要数周至数月的运行时间，这损害了将其转化为临床工作流程的有效性。本文采用了三种计算流体方法，不同程度的复杂性与耦合OD边界条件，模拟患者特定的主动脉内的血液动力学。最全面的模型是完整的FSI模拟。最简单的是刚性壁不可压缩流体模拟，而另一种中间方法采用可压缩流体，调整以引起类似于主动脉壁顺应性的响应。结果表明，在某些临床问题的背景下，更简单的分析方法可以捕获流场的重要特征。(C)2011爱思唯尔有限公司保留所有权利。
State of the art simulations of aortic haemodynamics feature full fluid-structure interaction (FSI) and coupled OD boundary conditions. Such analyses require not only significant computational resource but also weeks to months of run time, which compromises the effectiveness of their translation to a clinical workflow. This article employs three computational fluid methodologies, of varying levels of complexity with coupled OD boundary conditions, to simulate the haemodynamics within a patient-specific aorta. The most comprehensive model is a full FSI simulation. The simplest is a rigid walled incompressible fluid simulation while an alternative middle-ground approach employs a compressible fluid, tuned to elicit a response analogous to the compliance of the aortic wall. The results demonstrate that, in the context of certain clinical questions, the simpler analysis methods may capture the important characteristics of the flow field. (C) 2011 Elsevier Ltd. All rights reserved.