Developmental changes in distribution patterns of phencyclidine-induced c-Fos in rat forebrain
Developmental changes in distribution patterns of phencyclidine-induced c-Fos in rat forebrain
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DOI：
10.1016/s0304-3940(97)00879-3
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发表时间：
1997-12-12
影响因子：
2.5
通讯作者：
Nishikawa, T
中科院分区：
文献类型：
--
作者：
Sato, D;Umino, A;Nishikawa, T
在56日龄大鼠的前脑，组织化学研究表明，皮下注射拟精神病苯环利定(PCP；1和10 mg/kg)，在梨状皮质、新皮质和隔区的IV-VI层引起密集的c-fos免疫反应，而在嗅结节和中外侧纹状体有稀疏的c-fos免疫反应。出生后第8天的幼鼠在注射五氯苯酚后，新皮质中c-fos阳性细胞的表达明显多于幼年大鼠。然而，PCP诱导的c-Fos在梨状皮质、中外侧纹状体、嗅结节和隔区的表达模式在婴儿期和成年期之间相似。神经元活性标记物c-Fos区域分布的这些发育变化表明，参与PCP诱导的异常行为的神经元群体受到出生后发育的影响，至少在新皮质。(C)1997年爱思唯尔爱尔兰科学有限公司。
In the forebrain of 56-day-old rats, histochemical studies revealed that the subcutaneous injection of a psychotomimetic phencyclidine (PCP; 1 and 10 mg/kg) induced a dose-related and dense nuclear c-fos-like immunoreactivity in the pyriform cortex, layers IV-VI of the neocortex and septum, but a sparse c-Fos immunostaining in the olfactory tubercle and mid-lateral striatum. Infant rats at postnatal day 8 expressed much fewer and more confined c-fos-positive cells in the neocortex than young adult rats following PCP injection. However, a similar expression pattern of PCP-induced c-Fos was observed in the pyriform cortex, mid-lateral striatum, olfactory tubercle and septum between the infant and adult periods. These developmental changes in the regional distribution of a neuronal activity marker, c-Fos, suggest that neuronal populations involved in PCP-induced abnormal behavior are influenced by postnatal development, at least, in the neocortex. (C) 1997 Elsevier Science Ireland Ltd.