Oral estrogen treatment induces a decrease in expression of sialyl Lewis x on alpha(1)-acid glycoprotein in females and male-to-female transsexuals
Oral estrogen treatment induces a decrease in expression of sialyl Lewis x on alpha(1)-acid glycoprotein in females and male-to-female transsexuals
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DOI：
10.1093/glycob/6.4.407
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发表时间：
1996-06-01
期刊：
影响因子：
4.3
通讯作者：
VanDijk, W
中科院分区：
文献类型：
--
作者：
BrinkmanVanderLinden, ECM;Havenaar, EC;VanDijk, W
在使用口服避孕药的女性和接受口服或经皮雌激素治疗的男性变女性变性者中研究了雌激素对α 1-酸性糖蛋白糖基化的影响。与未接受雌激素或经皮雌激素治疗的个体相比，口服雌激素治疗诱导α 1-酸性糖蛋白上分支程度增加，岩藻糖基化和唾液酸刘易斯x表达减少，在接受口服雌激素联合醋酸环丙孕酮（一种具有孕激素样作用的雄激素受体阻断剂）的男性变女性变性者中，对α（1）-酸性糖蛋白糖基化的影响较小，这与使用含雌激素和孕激素的口服避孕药的女性相当。我们得出结论，口服雌激素对男性和女性的α（1）-酸性糖蛋白的肝糖基化具有相同的作用，孕激素降低了这种作用。这些结果表明，口服雌激素对α（1）-酸性糖蛋白糖基化的诱导作用与炎症诱导的作用相反。因此，口服雌激素可调节α（1）-酸性糖蛋白糖基化依赖性炎症作用，而经皮给药雌激素的情况并非如此。很可能，肝细胞上的雌激素受体在观察到的作用中起重要作用。
The effect of estrogen on the glycosylation of alpha(1)-acid glycoprotein was studied in women using oral contraceptives and in male-to-female transsexuals receiving oral or transdermal estrogen treatment, Oral estrogen treatment induced an increase in degree of branching and a decrease in fucosylation and sialyl Lewis x expression on alpha(1)-acid glycoprotein compared to individuals receiving no estrogens or transdermal estrogen treatment, The effect on the glycosylation of alpha(1)-acid glycoprotein was less in the male-to-female transsexuals receiving oral estrogens in combination with cyproterone acetate, a blocker of the androgen receptor with progestagen-like effects, This was of comparable magnitude as in women using oral contraceptives containing both estrogen and progestagen. We conclude that oral estrogens have an identical effect on the hepatic glycosylation of alpha(1)-acid glycoprotein in both males and females and that progestagen reduces this effect. These results show that oral estrogens induce an effect on the glycosylation of alpha(1)-acid glycoprotein opposite to that induced by inflammation, Oral estrogens can therefore modulate the glycosylation dependent inflammatory actions of alpha(1)-acid glycoprotein, while this is not the case with transdermal estrogens, In all likelihood, estrogen receptors on the hepatocyte must play a significant role in the observed effect.