Novel Potential Mechanisms for Diabetic Macular Edema: Leveraging New Investigational Approaches
Novel Potential Mechanisms for Diabetic Macular Edema: Leveraging New Investigational Approaches
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DOI：
10.1007/s11892-008-0047-5
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Antonetti, David A.
中科院分区：
文献类型：
--
作者：
Gardner, Thomas W.;Antonetti, David A.
本文对糖尿病眼部和全身炎症引起血视网膜屏障破坏导致黄斑水肿的分子机制进行了综述。我们还总结了分子靶点和临床前研究和临床试验中治疗性抑制剂的使用之间的关系。需要进一步的研究来了解正常血视网膜屏障生理学的调节以及糖尿病视网膜病变动物模型和糖尿病患者之间的关系。
This article evaluates the current knowledge of the molecular mechanisms by which diabetes ocular and systemic inflammation induce breakdown of the blood-retinal barrier resulting in macular edema. We also summarize the relationship between molecular targets and the use of therapeutic inhibitors in preclinical studies and clinical trials. Further studies are needed to understand the regulation of normal blood-retinal barrier physiology and the relationship between events in animal models of diabetic retinopathy and humans with diabetes.