VOXEL-BASED MORPHOMETRY STUDY OF THE INSULAR CORTEX IN FEMALE PATIENTS WITH CURRENT AND REMITTED DEPRESSION
VOXEL-BASED MORPHOMETRY STUDY OF THE INSULAR CORTEX IN FEMALE PATIENTS WITH CURRENT AND REMITTED DEPRESSION
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基于体素的抑郁症女性患者岛叶形态测量研究
DOI：
10.1016/j.neuroscience.2013.12.058
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发表时间：
2014-03-14
期刊：
影响因子：
3.3
通讯作者：
Wang, C-Y
中科院分区：
文献类型：
--
作者：
Liu, C-H;Jing, B.;Wang, C-Y
目的：女性更易患重性抑郁障碍（MDD），女性MDD的发病率几乎是男性的两倍。岛叶皮质异常是MDD患者神经解剖学研究的常见结果。然而，在很大程度上还不清楚女性MDD患者在不同的临床阶段是否表现出岛叶皮质特定亚区的形态学变化。此外，它是不理解的，如果任何子区域的变化可以被用作一个国家或性状标记的MDD，以及任何标记的诊断性能是否足以识别MDD.Methods：19右撇子目前MDD（cMDD）的女性患者和19缓解MDD（rMDD）患者，以及19名健康对照组的年龄和教育水平相匹配，被招募到这项研究。通过基于体素的形态测量（VBM），我们调查了三组中岛状亚区的灰质体积异常，并进一步进行了基于感兴趣区域（ROI）的受试者工作特征（ROC）分析。从这些调查的数据与临床数据，以确认在区分three groups.Results的亚区域中的确定的变化的有效性：无论是cMDD和rMDD组显示出显着减少灰质体积在左背前额叶与健康对照组相比。与健康对照组相比，cMDD组的右背前额叶灰质体积也有所减少。进一步的ROC比较表明，左背前岛叶皮质可以有效地区分cMDD和rMDD组与健康controls.Conclusions：我们的研究结果表明，左背前岛叶皮质的体积变化可能是一个特质相关的标志物，对MDD的脆弱性和右背前岛叶皮质可能涉及MDD的病理变化。(C)2014年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Objective: Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stages show morphologic changes in a specific subregion of the insular cortex. Additionally, it is not understood if any subregion changes can be used as a state or trait marker of MDD, and whether the diagnostic performance of any marker is sufficient to identify MDD.Methods: Nineteen right-handed current MDD (cMDD) female patients and 19 remitted MDD (rMDD) patients, as well as 19 healthy controls matched for age and educational level, were recruited into the study. By means of voxel-based morphometry (VBM), we investigated gray matter volume abnormalities in insular subregions among the three groups and further conducted region-of-interest (ROI)-based receiver operating characteristic (ROC) analyses. The data from these investigations were correlated with clinical data to confirm the effectiveness of the identified changes in the subregions in differentiating the three groups.Results: Both the cMDD and rMDD groups showed significantly decreased gray matter volumes in the left dorsal anterior insula compared to the healthy controls. The cMDD groups also showed decreased gray matter volumes in the right dorsal anterior insula relative to healthy controls. Further ROC comparisons demonstrated that the left dorsal anterior insula can effectively differentiate cMDD and rMDD groups from healthy controls.Conclusions: Our findings suggest that the volume changes in the left dorsal anterior insular cortex may be a trait-related marker of vulnerability to MDD and that the right dorsal anterior insular cortex may involve pathological changes of MDD. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.