Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662
Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662
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DOI：
10.1038/ja.2009.70
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发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Fiedler, Hans-Peter
中科院分区：
文献类型：
--
作者：
Helaly, Soleiman;Schneider, Kathrin;Fiedler, Hans-Peter
Gombapyrones A-D是从竹子根际分离到的灰色链霉菌Acta 3662产生的α-吡喃酮类次生代谢产物。对该菌株进行了形态和化学分类鉴定，并进行了16S rDNA序列测定，确定其为灰色链球菌。通过质谱学和核磁共振实验确证了其结构，发现其对蛋白酪氨酸磷酸酶1B和糖原合成酶3β具有抑制活性。《抗生素杂志》(2009年)62445452；doi：10.1038/ja.2009.70；在线出版
Gombapyrones A-D, new members of the a-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3 beta. The Journal Antibiotics (2009) 62, 445-452; doi:10.1038/ja.2009.70; published online 31 July 2009