IN VIVO STUDIES ON THE METABOLISM OF [15,16‐3H]TETRACOSANOIC ACID (LIGNOCERIC ACID) IN ADULT RAT BRAIN
IN VIVO STUDIES ON THE METABOLISM OF [15,16‐3H]TETRACOSANOIC ACID (LIGNOCERIC ACID) IN ADULT RAT BRAIN
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[15,16-3H]二十四烷酸(二十四烷酸)在成年大鼠脑内代谢的体内研究
DOI:
10.1111/j.1471-4159.1975.tb04377.x
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发表时间:
1975
影响因子:
4.7
通讯作者:
H. Jatzkewitz
中科院分区:
文献类型:
--
作者:
D. Seidel;G. Nowoczek;H. Jatzkewitz
—Adult rats were killed 16 h, 48 h, 6 days and 21 days after intracerebral application of n‐[15,16‐3H]tetracosanoic acid (lignoceric acid). After incorporation into complex lipids with a strong preference for the ester‐bound fatty acids of glycerophospholipids, radioactivity decreased with time. The incorporated activity into the amide‐bound fatty acids of sphingolipids was also shown to decrease, with exception of the cerebroside of the hydroxy fatty acid type (cerebron fraction). Only negligible amounts of labelled triglyceride and cholesterol ester could be detected.