Neutrophil extracellular traps: double-edged swords of innate immunity.
Neutrophil extracellular traps: double-edged swords of innate immunity.
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DOI：
10.4049/jimmunol.1201719
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发表时间：
2012-09-15
期刊：
影响因子：
--
通讯作者：
Radic M
中科院分区：
文献类型：
--
作者：
Kaplan MJ;Radic M
2004年首次报道了中性粒细胞喷射核染色质和杀菌蛋白对微生物的反应的壮观图像。由于外化的染色质可以缠绕细菌，这些结构被称为中性粒细胞外陷阱(Nets)。随后的研究确定了刺激Net的微生物和无菌条件，以及释放细胞外染色质的其他细胞类型。Nets的释放是细胞死亡过程中最戏剧性的阶段，被称为NETsis。实验证据表明，Net参与了自身免疫性和炎症性疾病的发病机制，并被认为参与了肾小球肾炎、慢性肺部疾病、败血症和血管疾病。净值增大或净值间隙减小可能会增加净值成分发生自身反应的风险。NETS的生物学意义才刚刚开始被探索。在免疫学和病理生理学中更全面地整合蚊虫感染将需要更好地了解与特定疾病状态和微生物感染相关的蚊帐特性。这可能导致确定重要的治疗靶点。
Spectacular images of neutrophils ejecting nuclear chromatin and bactericidal proteins, in response to microbes, were first reported in 2004. As externalized chromatin could entangle bacteria, these structures were named neutrophil extracellular traps (NETs). Subsequent studies identified microorganisms and sterile conditions that stimulate NETs, and additional cell types that release extracellular chromatin. NETs’ release is the most dramatic stage in a cell death process called NETosis. Experimental evidence suggests that NETs participate in pathogenesis of autoimmune and inflammatory disorders, with proposed involvement in glomerulonephritis, chronic lung disease, sepsis and vascular disorders. Exaggerated NETosis or diminished NET clearance likely increases risk of autoreactivity to NET components. The biological significance of NETs is just beginning to be explored. A more complete integration of NETosis within immunology and pathophysiology will require better understanding of NET properties associated with specific disease states and microbial infections. This may lead to the identification of important therapeutic targets.
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DOI：
10.1073/pnas.0900226106
发表时间：
2009-04-21
影响因子：
11.1
作者：
Guimaraes-Costa, Anderson B.;Nascimento, Michelle T. C.;Saraiva, Elvira M.
通讯作者：
Saraiva, Elvira M.
影响因子：
2.7
作者：
Gupta, AK;Hasler, P;Hahn, S
通讯作者：
Hahn, S
影响因子：
4.4
作者：
Cocca, BA;Cline, AM;Radic, MZ
通讯作者：
Radic, MZ
影响因子：
37.8
作者：
Doering, Yvonne;Manthey, Helga D.;Zernecke, Alma
通讯作者：
Zernecke, Alma
DOI：
10.1111/j.1538-7836.2011.04544.x
发表时间：
2012-01
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Brill A;Fuchs TA;Savchenko AS;Thomas GM;Martinod K;De Meyer SF;Bhandari AA;Wagner DD
通讯作者：
Wagner DD