Death of parent, sibling, spouse, and child in a Swedish national sample and risk of subsequent stress reaction, major depression, alcohol-use disorder, and drug-use disorder.
Death of parent, sibling, spouse, and child in a Swedish national sample and risk of subsequent stress reaction, major depression, alcohol-use disorder, and drug-use disorder.
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DOI：
10.1017/s0033291723000570
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发表时间：
2023-11
影响因子：
6.9
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Kendler, Kenneth S.;Lonn, Sara L.;Sundquist, Jan;Sundquist, Kristina
确定在一般人群中，近亲死亡后应激反应（SR）、重度抑郁（MD）、酒精使用障碍（AUD）和药物使用障碍（DUD）的发生率增加多少。SR、MD、AUD和DUD注册来自瑞典国家注册中心。从2000年至2018年随访的人群中，将2002年至2016年暴露于近亲死亡的人群与未暴露的对照人群进行匹配，并使用差异中的差异方法通过对照前后设计对男性和女性进行分析。在有子女的男性和女性亲属死亡后，SR的风险显著、短暂增加，MD的风险延长幅度更小，其次是配偶、父母和兄弟姐妹。在亲属死亡后，也观察到AUD而非DUD相对持久的适度增加。女性SR和MD的绝对增加大于男性，男性AUD的绝对增加大于女性。然而，逻辑回归分析显示，大多数影响并没有显着差异的性别。随着年轻父母、兄弟姐妹和配偶的死亡，以及儿童意外死亡与非意外死亡，疾病风险增加幅度一致。将匹配队列设计应用于瑞典人口登记研究，近亲死亡与SR、MD和AUD发生率大幅增加相关，并可能导致SR、MD和AUD发生率大幅增加，这与先前较小的临床研究一致。通过这样的登记，我们可以在大量的代表性样本中，将暴露于选定的环境逆境的影响整合到疾病风险途径中。
To determine, in a general population, how much rates of stress reactions (SR), major depression (MD), alcohol-use disorder (AUD) and drug-use disorder (DUD) increase after the death of close relatives. SR, MD, AUD, and DUD registrations were assessed from national Swedish registries. From the population followed from 2000 to 2018, those exposed to death of a close relative in 2002–2016 were matched to unexposed controls and analyzed in males and females by a controlled pre-post design using a difference-in-difference method. Substantial, brief increases in risk for SR and more modest prolonged increases in MD were observed after death of relatives in both men and women greatest with children, followed by spouses, parents, and siblings. Relatively long-lasting modest increases in AUD but not DUD were also observed following death of relatives. The absolute increases for SR and MD were greater in females than males and for AUD greater in males than females. However, logistic regression analyses showed most effects did not differ significantly by sex. Consistently larger increases in disorder risk were seen with the death of younger v. older parents, siblings, and spouses and with accidental v. non-accidental death in children. Applying a matched cohort design to Swedish population registries, death of close relatives was associated with, and likely caused, substantial increases in rates of SR, MD, and AUD, consistent with smaller prior clinical investigations. Through such registries, we can, in large representative samples, integrate the impact of exposures to selected environmental adversities into disorder risk pathways.
影响因子：
4.4
作者：
Li, Dian-Jeng;Tsai, Shih-Jen;Chen, Tzeng-Ji;Liang, Chih-Sung;Chen, Mu-Hong
通讯作者：
Chen, Mu-Hong