Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder
Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder
复制标题
DOI：
10.1176/appi.ajp.163.7.1173
复制
发表时间：
2006-07-01
影响因子：
17.7
通讯作者：
Dyck, Ingrid
中科院分区：
文献类型：
--
作者：
Gunderson, John G.;Weinberg, Igor;Dyck, Ingrid
目的：研究边缘型人格障碍是否为双相情感障碍的变异型，考察两种障碍的共现率、共发生对纵向病程的影响，以及其中一种障碍的存在是否增加了另一种障碍新发病的风险。方法：采用前瞻性重复测量设计，采用独立诊断方法可靠，并进行4年随访，对196例边缘型人格障碍患者和433例其他人格障碍患者进行评估。结果：边缘型人格障碍患者双相情感障碍的发生率(19.4%)显著高于其他人格障碍患者。然而，这种共同发生似乎并没有影响随后的边缘性人格障碍的病程。虽然只有8.2%的临界性人格障碍患者出现了新的双相情感障碍，但这一比例高于其他人格障碍患者。伴发双相情感障碍的其他人格障碍患者一般比无双相情感障碍的其他人格障碍患者有更多的临界性人格障碍(25%)新发病(10%)。
Objective: The purpose of this study was to test whether borderline personality disorder is a variant of bipolar disorder by examining the rates of co- occurrence in both disorders, the effects of co- occurrence on a longitudinal course, and whether the presence of either disorder confers the risk for new onsets of the other.Method: A prospective repeated- measures design with reliable independent diagnostic measures and 4 years of followup was used to assess 196 patients with borderline personality disorder and 433 patients with other personality disorders.Results: Patients with borderline personality disorder had a significantly higher co- occurrence of bipolar disorder ( 19.4%) than did patients with other personality disorders. However, this co- occurrence did not appear to affect the subsequent course of borderline personality disorder. Although only 8.2% of the borderline personality disorder patients developed new onsets of bipolar disorder, this rate was higher than in patients with other personality disorders. Patients with other personality disorders with co- occurring bipolar disorder generally had more new onsets of borderline personality disorder ( 25%) than did patients with other personality disorders without co- occurring bipolar disorder ( 10%).Conclusions: A modest association between borderline personality disorder and bipolar disorder is reported.