Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis.
Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis.
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血清 Dickkopf-1 升高是银屑病关节炎患者骨侵蚀的生物标志物。
DOI：
10.1097/cm9.0000000000001612
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发表时间：
2021-07-15
影响因子：
6.1
通讯作者：
Zhang XW
中科院分区：
文献类型：
--
作者：
Chung Y;Li ZC;Sun XL;Liu YY;Shao M;Gan YZ;Li YM;Li YH;Zhang XW
银屑病性关节炎（Psoriatic arthritis，PsA）是一种以银屑病和骨侵蚀为主要影像学特征的炎症性关节病。Dickkopf-1（Dkk-1）被认为是Wnt信号通路的主要抑制剂，并导致成骨细胞增殖减少。本研究旨在探讨银屑病患者血清Dkk-1水平及其与骨侵蚀的关系。采用酶联免疫吸附法（ELISA）检测69例PsA患者和60例健康对照者（包括39例类风湿关节炎（RA）患者和21例健康对照者）血清Dkk-1水平。还通过ELISA测定了风湿因子和抗环瓜氨酸肽水平。分析Dkk-1水平与PsA临床及实验室特征的关系。采用Logistic回归分析PsA骨质侵蚀的危险因素。Dkk-1在PsA组、RA组和HC组中的阳性率分别为68.1%（47/69）、46.2%（18/39）和9.5%（2/21）。PsA患者血清Dkk-1浓度显著高于HC患者。血清Dkk-1水平与肿胀关节计数、补体成分3和4水平相关。Dkk-1水平升高（比值比= 4.440，95%可信区间：1.246-15.817，P = 0.021）被确定为PsA患者骨侵蚀的危险因素。 PsA患者血清Dkk-1水平异常升高。Dkk-1的升高可能参与了PsA骨侵蚀的发生机制。
Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients. Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 69 patients with PsA and 60 controls, including 39 rheumatoid arthritis (RA) patients, and 21 healthy controls (HCs). Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by ELISA. The association of Dkk-1 level with clinical and laboratory features of PsA was analyzed. Logistic regression analysis was used to analyze the risk factors for bone erosion in PsA. Dkk-1 was elevated in 68.1% (47/69) of the patients with PsA, 46.2% (18/39) of RA patients, and 9.5% (2/21) of HCs. Serum Dkk-1 concentration was significantly higher in PsA patients compared with that in HCs. The level of serum Dkk-1 was correlated with a swollen joint count, and levels of complement components 3 and 4. Elevated Dkk-1 level (odds ratio = 4.440, 95% confidence interval: 1.246–15.817, P = 0.021) was identified as the risk factor for bone erosion in PsA. The serum level of Dkk-1 is abnormally elevated in PsA patients. The elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.