Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2 disruption
Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2 disruption
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DOI：
10.1073/pnas.2106378118
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发表时间：
2021-10-26
影响因子：
11.1
通讯作者：
Shew，Woodrow L.
中科院分区：
文献类型：
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作者：
Li，Jingwen;Kells，Patrick A.;Shew，Woodrow L.
复杂的身体运动需要复杂的动力学和运动皮层神经元之间的协调。相反，一个长期存在的理论观点认为，如果运动皮层中的许多神经元变得过度同步，它们可能缺乏健康运动编码所需的复杂性。然而，对这一观点的直接实验支持很少，潜在的机制也不清楚。在此，我们记录了突触抑制增强的大鼠和Rett综合征（RTT）转基因大鼠模型的运动皮层中许多单个神经元的三维身体运动和尖峰活动。在这两种情况下，我们都发现了运动系统复杂性的崩溃。在低维度、刻板的脑-体互动、神经同步和更简单的行为中，复杂性明显降低。我们的研究结果表明，不平衡的抑制如何导致运动相关神经元之间的过度同步，从而导致刻板的运动代码。过度抑制和同步可能是RTT异常运动功能的基础。
Complex body movements require complex dynamics and coordination among neurons in motor cortex. Conversely, a long-standing theoretical notion supposes that if many neurons in motor cortex become excessively synchronized, they may lack the necessary complexity for healthy motor coding. However, direct experimental support for this idea is rare and underlying mechanisms are unclear. Here we recorded three-dimensional body movements and spiking activity of many single neurons in motor cortex of rats with enhanced synaptic inhibition and a transgenic rat model of Rett syndrome (RTT). For both cases, we found a collapse of complexity in the motor system. Reduced complexity was apparent in lower-dimensional, stereotyped brain–body interactions, neural synchrony, and simpler behavior. Our results demonstrate how imbalanced inhibition can cause excessive synchrony among movement-related neurons and, consequently, a stereotyped motor code. Excessive inhibition and synchrony may underlie abnormal motor function in RTT.