Inflammation: Roles in Aging and Sarcopenia
Inflammation: Roles in Aging and Sarcopenia
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DOI：
10.1177/0148607108324585
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发表时间：
2008-11-01
影响因子：
3.4
通讯作者：
Jensen, Gordon L.
中科院分区：
文献类型：
--
作者：
Jensen, Gordon L.
衰老与炎症性慢性疾病有关，如肥胖、心血管疾病、胰岛素抵抗和关节炎。肌肉萎缩症--随着年龄的增长而出现的肌肉萎缩--是多因素的，其影响因素可能包括α-运动神经元输入的丧失、合成代谢激素的变化、膳食蛋白质摄入量的减少以及体力活动的减少。研究结果表明，肌肉减少症是由细胞因子和氧化应激驱动的闷烧炎症状态。经常检测到白细胞介素-6和C反应蛋白水平升高。肌萎缩性肥胖症表现为肥胖和相关脂肪因子增加的炎症负担。对肌肉减少症的潜在干预包括营养补充剂、体力活动/抗阻力锻炼、热量限制、合成代谢激素、抗炎剂和抗氧化剂。一个关键问题是肌肉减少症是否真的是一种独特的综合征或恶病质连续体的一种较温和的形式。(JPEN《胃肠外营养学杂志》2008; 32：656 - 659）
Aging is associated with inflammatory chronic conditions such as obesity, cardiovascular disease, insulin resistance, and arthritis. Sarcopenia-muscle loss with aging-is multifactorial with contributing factors that may include loss of alpha-motor neuron input, changes in anabolic hormones, decreased intake of dietary protein, and decline in physical activity. Research findings suggest that sarcopenia is a smoldering inflammatory state driven by cytokines and oxidative stress. Elevated levels of interleukin-6 and C-reactive protein are often detected. Sarcopenic obesity manifests the added inflammatory burden of adiposity and associated adipokines. potential interventions for sarcopenia include nutritional supplements, physical activity/resistance exercise, caloric restriction, anabolic hormones, anti-inflammatory agents, and antioxidants. A key question is whether sarcopenia is truly a distinct syndrome or a milder form of a cachexia continuum. (JPEN J Parenter Enteral Nutr. 2008;32:656-659)