Central cardiovascular action of urotensin II in spontaneously hypertensive rats
Central cardiovascular action of urotensin II in spontaneously hypertensive rats
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DOI：
10.1291/hypres.26.839
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发表时间：
2003-10-01
影响因子：
5.4
通讯作者：
Iida, M
中科院分区：
文献类型：
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作者：
Lin, YZ;Tsuchihashi, T;Iida, M
我们以前曾报道，尾加压素II作用于中枢神经系统，增加血压正常大鼠的血压。在本研究中，我们观察了尾加压素II对自发性高血压大鼠（SHR）的中枢心血管作用。侧脑室注射尾加压素II可引起SHR和正常血压的WKY大鼠血压呈剂量依赖性升高。在WKY中，ICV尾加压素II在1和10 nmol剂量下诱导的平均动脉压变化分别为8+/-2和23+/-3 mmHg。尾加压素II的ICV给药使SHR的血压显著升高（1 nmol时为16 ± 3 mmHg，10 nmol时为35 ± 3 mmHg）。尾加压素II（10 nmol）引起SHR（107+/-10 bpm）和WKY（101+/-21 bpm）的心率显著增加。侧脑室注射10 nmol尾加压素II后，SHR和WKY的血浆肾上腺素浓度分别为203+/-58pmol/ml和227+/-47pmol/ml，高于人工脑脊液注射大鼠（分别为73+/-7和87+/-28pmol/ml，P < 0.01）。
We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats. In the present study, we have determined the central cardiovascular action of urotensin II in spontaneously hypertensive rats (SHR). Intracerebroventricular (ICV) injection of urotensin II elicited a dose-dependent increase in blood pressure in both SHR and normotensive Wistar-Kyoto rats (WKY). The changes in mean arterial pressure induced by ICV urotensin II at doses of 1 and 10 nmol in the WKY were 8+/-2 and 23+/-3 mmHg, respectively. ICV administration of urotensin II caused significantly greater increases in blood pressure in SHR (16+/-3 mmHg at 1 nmol and 35+/-3 mmHg at 10nmol, respectively) compared with those in WKY. Urotensin II (10 nmol) elicited significant and comparable increases in heart rate in SHR (107+/-10 bpm) and WKY (101+/-21 bpm). Plasma epinephrine concentrations after ICV administration of 10nmol urotensin II were 203+/-58 pmol/ml in SHR and 227+/-47 pmol/ml in WKY, which tended to be higher than those in artificial cerebrospinal fluid-injected rats (73+/-7 and 87+/-28 pmol/ml, respectively, p