Kinetic parameters and the course of the disease in breast cancer
Kinetic parameters and the course of the disease in breast cancer
复制标题
乳腺癌的动力学参数和病程
DOI：
10.1002/1097-0142(19810301)47:5
复制
发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
Prof. M. Tubiana
中科院分区：
文献类型：
--
作者：
MD M. TUBIANA;MD M. J. PEJOVIC;MD A. RENAUD;MD G. CONTESSO;N. Chavaudra;'. J. GIOANNI;MD E. P. MALAISE;Centre;Prof. M. Tubiana
本文对128例原发性乳腺肿瘤的标记指数（LI）与初次治疗后病程的相关性进行了前瞻性研究。用氚化胸苷体外孵育乳腺肿瘤手术标本，并进行放射自显影。患者接受了简单的乳房切除术和腋窝淋巴结清扫术;发现一个或多个淋巴结受累的患者接受了术后放疗。所有患者均未接受辅助化疗。由于治疗时LI未知，因此其值不影响治疗选择。所有患者的随访期均超过6年。LI越高，从初始治疗到首次复发或从首次复发到死亡的时间间隔越短。此外，LI与无复发生存期和生存率之间存在显著相关性。低LI组的复发比例特别小。曲线的形状表明，该组的结果将优于高LI或中LI组。
The correlation between the labeling index (LI) of the primary mammary tumor and the course of the disease after initial treatment was studied prospectively on 128 patients. The surgical specimens of breast tumors were incubated in vitro with tritiated thymidine and autoradiographies were performed. Patients were treated by a simple mastectomy and axillary lymph nodes dissection; patients in whom one or more lymph nodes were found to be involved received postoperative radiotherapy. None of the patients received adjuvant chemotherapy. As the LIs were not known at the time of treatment, their values did not influence the choice of therapy. The follow‐up period is greater than six years for all patients. The higher the LI, the shorter were the time intervals from initial treatment to first relapse or from first relapse to death. Moreover, significant correlations were found between the LI and the relapse‐free survival and the survival rates. The proportion of relapses was particularly small in the group with the low LI. The shape of the curve suggests that the outcome in this group will be better than that in the group with a high or a median LI.
DOI：
--
发表时间：
1972
期刊：
--
影响因子：
--
作者：
D. Cox
通讯作者：
D. Cox