Asthma in every fifth child in Oslo, Norway:: a 10-year follow up of a birth cohort study
Asthma in every fifth child in Oslo, Norway:: a 10-year follow up of a birth cohort study
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DOI：
10.1111/j.1398-9995.2005.00938.x
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发表时间：
2006-04-01
期刊：
影响因子：
12.4
通讯作者：
Carlsen, KH
中科院分区：
文献类型：
--
作者：
Carlsen, KCL;Håland, G;Carlsen, KH
背景：建议西方世界儿童哮喘的增长趋于平稳。我们的目的是在1992/1993年在奥斯陆建立的前瞻性出生队列环境和儿童哮喘（ECA）研究中调查10岁儿童的哮喘患病率。对象和方法：对803名出生时肺功能测量的儿童（平均年龄10.9±0.9 （SD）岁）中的616名（77%）在10岁时进行再调查。在出生时，他们与整个出生队列（n = 3754）在性别、社会人口因素、父母过敏疾病、养宠物和母亲吸烟方面相对应。本文介绍了有组织的父母访谈、肺活量测定和吸入物和食物过敏原皮肤点刺试验的结果。哮喘定义至少需要两个阳性标准，(i)医生对哮喘的诊断，（ii）喘息和/或胸闷，（iii）使用抗哮喘治疗。当前哮喘需要哮喘定义加上过去12个月的（ii）和/或（iii），和/或>=跑步机跑步后1秒内强制呼气量下降10%。结果：哮喘终生患病率为20.2%；目前哮喘11.1%，医生诊断为哮喘16.1%，曾有喘息30.3%。与无症状（过去12个月）（26.0%）或无哮喘（27.6%）相比，当前哮喘患儿（56.3%）的过敏性致敏（29.3%）更为常见（P < 0.001）。男孩比女孩有更多的哮喘（14.4比7.1%,P = 0.004）、喘息（36.9比22.5%,P = 0.002）和过敏致敏（36.2比22.1%,P < 0.001）。结论：儿童哮喘在奥斯陆明显继续增加，每五个10岁儿童中就有一个受到影响。
Background: The western world's increase in childhood asthma is suggested to level off. We aimed to investigate asthma prevalence in 10-year-old children within the prospective birth cohort Environment and Childhood Asthma (ECA) Study in Oslo established in 1992/1993.Subjects and methods: Six hundred and sixteen (77%) of 803 children (mean age 10.9 +/- 0.9 (SD) years) with lung function measurements at birth were reinvestigated at age 10 years. At birth they corresponded to the entire birth cohort (n = 3754) regarding gender, socio-demographic factors, parental allergic diseases, pet keeping and maternal smoking. Results from structured parental interview, spirometry, and skin prick test for inhalant and food allergens are presented. Asthma definition required minimum two positive criteria, (i) doctor's diagnosis of asthma, (ii) wheeze and/or chest tightness, (iii) use of anti-asthmatic treatment. Current asthma required asthma definition plus either (ii) and/or (iii) in the last 12 months, and/or >= 10% fall in forced expired volume in 1 s after treadmill running.Results: Lifetime prevalence of asthma was 20.2%; current asthma 11.1%, doctor diagnosis of asthma 16.1% and wheezes ever 30.3%. Allergic sensitization (29.3% overall) was more common among children with current (56.3%) compared to asymptomatic (last 12 months) (26.0%) or no asthma (27.6%) (P < 0.001). Boys more often than girls had current asthma (14.4 vs 7.1%, P = 0.004), wheeze ever (36.9 vs 22.5%, P = 0.002) and allergic sensitization (36.2 vs 22.1%, respectively, P < 0.001).Conclusion: Childhood asthma apparently continues to increase in Oslo, having affected every fifth 10-year-old child.