Iron status in 72 Congolese patients with sickle cell anemia
Iron status in 72 Congolese patients with sickle cell anemia
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DOI：
10.1684/mst.2016.0535
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发表时间：
2016-01-01
影响因子：
--
通讯作者：
Nzongola, Kayembe D.
中科院分区：
文献类型：
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作者：
Tshilolo, L.;Ngole, Zita M.;Nzongola, Kayembe D.
多次输血、肠道寄生虫和生长期的高铁需求都是影响非洲儿童铁状况的因素。为了确定他们的铁状态及其与这些因素的关系，我们研究了金沙萨72例处于稳定状态的纯合子镰状细胞病患者。铁状态由几个指标的组合确定：铁蛋白、转铁蛋白、血细胞计数、总铁结合力、转铁蛋白饱和度和C反应蛋白。将这些结果与无镰状细胞病的对照组进行比较。与对照组相比，5例患者（11%）缺铁，18例（35%）铁超载，可能是由于多次输血。这项研究表明，定期评估纯合子镰状细胞患者的铁状态，以预防和管理任何铁失衡的重要性。
Multiple blood transfusions, intestinal parasites, and high iron needs during the growth period are all factors that influence iron status in African children. To determine their iron status and its association with these factors, we studied 72 homozygous sickle-cell patients in a steady state in Kinshasa. Iron status was determined by a combination of several indicators: ferritin, transferrin, blood count, total iron binding capacity, transferrin saturation, and C-reactive protein. These results were compared with those from a matched control group without sickle-cell disease. Compared to the control group, 5 patients (11%) were iron deficient, while 18 (35%) had an iron overload, probably due to multiple blood transfusions. This study shows the importance of periodic assessments of iron status in homozygous sickle cell patients to prevent and manage any iron imbalance.