Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
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DOI：
10.1016/s0014-2999(00)00003-0
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发表时间：
2000-03-30
影响因子：
5
通讯作者：
Pidoplichko, VI
中科院分区：
文献类型：
--
作者：
Dani, JA;Radcliffe, KA;Pidoplichko, VI
本研究解决了来自海马体、腹侧被盖区和黑质的烟碱乙酰胆碱受体脱敏引起的两个问题。首先，生物物理研究可以发现尼古丁受体的有效和完全脱敏：但体内研究经常发现，脱敏对行为的影响并不完全，或者在不同的尼古丁浓度范围内脱敏是重要的。我们的研究结果表明，当比较来自大脑同一区域的附近神经元时，脱敏可能存在显著差异。因此，少数神经元上的尼古丁受体可能在可产生显著脱敏的条件下保持活跃并维持行为。其次，用于激活烟碱受体的激动剂也会引起脱敏。当前的条件和激动剂的应用和去除速度将控制激活和脱敏的程度。这些和其他因素在实验和生理上调节尼古丁激动剂的功效。(C) 2000 Elsevier Science B.V.版权所有
This study addresses two issues arising from the desensitization of nicotinic acetylcholine receptors from the hippocampus, ventral tegmental area, and substantia nigra. First, biophysical studies can find potent and complete desensitization of nicotinic receptors: but in vivo studies often find that desensitization affecting a behavior is less than complete, or that desensitization is important over a different nicotine concentration range. Our results show that there can be significant differences in desensitization when comparing nearby neurons from the same area of the brain. Thus, nicotinic receptors on a minority of neurons may remain active and maintain a behavior under conditions that can produce significant desensitization. Second, agonist applications that are intended to active nicotinic receptors also cause desensitization. The prevailing conditions and the rate of agonist application and removal will control the degree of activation vs. desensitization. These and other factors regulate the efficacy of nicotinic agonists experimentally and physiologically. (C) 2000 Elsevier Science B.V. All rights reserved.