Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?
Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?
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DOI：
10.1007/s10461-015-1119-6
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发表时间：
2016-03
影响因子：
4.4
通讯作者：
Ingersoll KS
中科院分区：
文献类型：
--
作者：
Read G;Ingersoll KS
这是对一项随机试验数据的二次分析，该试验对可卡因使用障碍的非依从性HIV患者进行双重重点干预。我们研究了基线人口统计学、心理学、精神病学和行为特征与研究后6个月ART依从性、对数病毒载量（VL）、ASI药物综合评分和使用可卡因天数之间的关系。我们使用SAS GLMSELECT程序来构建每个研究后结果的多变量模型。研究后ART依从性与2个心理变量相关;而logVL与2个药物相关行为相关。ASI药物综合评分与2种精神疾病、1种人口统计学和1种心理变量相关;相反，使用可卡因的天数与1种行为变量和3种心理变量相关。分析表明，行为，心理和精神病诊断因素与研究后ART依从性和可卡因使用结果之间存在明确，可靠的关系。未来对可卡因使用者的ART依从性干预应考虑针对这些患者特征进行调整。
This is a secondary analysis of data from a randomized trial of dually-focused interventions for nonadherent HIV patients with cocaine use disorders. We examined the relationships among baseline demographic, psychological, psychiatric, and behavioral characteristics and 6-months post-study ART adherence, log Viral Load (VL), ASI Drug Composite Score, and days using cocaine. We used the SAS GLMSELECT procedure to build multivariate models of each post-study outcome. Post-study ART adherence was related to 2 psychological variables; while logVL was related to 2 drug-related behaviors. ASI Drug Composite score was related to 2 psychiatric disorders, 1 demographic, and 1 psychological variable; in contrast, days using cocaine related to 1 behavioral and 3 psychological variables. Analyses show clear, robust relationships among behavioral, psychological and psychiatric diagnosis factors with post-study ART adherence and cocaine use outcomes. Future ART adherence interventions for cocaine users should consider tailoring to these patient characteristics.