The concept of the personal vitamin D response index
The concept of the personal vitamin D response index
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DOI：
10.1016/j.jsbmb.2016.12.011
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发表时间：
2018-01-01
影响因子：
4.1
通讯作者：
Haq, Afrozul
中科院分区：
文献类型：
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作者：
Carlberg, Carsten;Haq, Afrozul
当暴露于UV-B时，人类能够在皮肤中合成维生素D-3，但季节变化，纺织品覆盖和主要的室内活动往往需要补充这种化合物。关于理想的维生素D状态存在一些争议，通过最稳定的维生素D-3代谢物25-羟基维生素D-3的血清浓度和各自推荐的每日补充剂来测量。一个可能的答案可以通过描述补充维生素D的分子反应效率的个人维生素D反应指数的概念来提供。该概念基于维生素D-3通过其代谢物1 α，25-二羟基维生素D-3激活转录因子维生素D受体，从而对许多人体组织和细胞类型的表观基因组和转录组具有直接影响的事实。通过测量维生素D敏感的分子参数，例如表观遗传状态的变化和来自血液的移动的免疫细胞的基因的相应转录或血清中蛋白质或代谢物的水平，可以将个体区分为对维生素D的高、中和低应答者。因此，我们认为，维生素D补充剂的需要取决于维生素D状态与个人维生素D反应指数的关系，而不是单独的维生素D状态。(C)2016爱思唯尔有限公司版权所有
Humans are able to synthesize vitamin D-3 in their skin when exposed to UV-B, but seasonal variations, textile coverage and predominant indoor activities often make supplementation with the compound necessary. There is some dispute on the desired vitamin D status, measured via the serum concentration of the most stable vitamin D-3 metabolite, 25-hydroxyvitamin D-3, and the respective recommended daily supplementation. A possible answer may be provided by the concept of the personal vitamin D response index describing the efficiency of the molecular response to supplementation with vitamin D. The concept is based on the fact that vitamin D-3 activates via its metabolite 1 alpha,25-dihydroxyvitamin D-3 the transcription factor vitamin D receptor and thus has a direct effect on the epigenome and transcriptome of many human tissues and cell types. Individuals can be distinguished into high, mid and low responders to vitamin D via measuring vitamin D sensitive molecular parameters, such as changes in the epigenetic status and the respective transcription of genes of mobile immune cells from blood or the level of proteins or metabolites in serum. Thus, we suggest that the need for vitamin D supplementation depends on the vitamin D status in relation to the personal vitamin D response index of an individual rather than on the vitamin D status alone. (C) 2016 Elsevier Ltd. All rights reserved.