Does milk increase mucus production?
Does milk increase mucus production?
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DOI：
10.1016/j.mehy.2009.10.044
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发表时间：
2010-04-01
影响因子：
4.7
通讯作者：
McGlashan, Susan Read
中科院分区：
文献类型：
--
作者：
Bartley, Jim;McGlashan, Susan Read
长期以来，牛奶摄入过多与呼吸道粘液分泌增加和哮喘有关。这种关联不能用传统的过敏范式来解释，而且显示因果关系的医学证据有限。在人类结肠中，β -casomorphin-7 （β - cm -7）是一种从A1牛奶分解中提取的外啡素，它能刺激肠道MUC5AC腺体产生粘液。在存在炎症的情况下，呼吸道MUC5AC腺体产生类似的粘液过量是许多呼吸道疾病的特征。血液中的- cm -7可以刺激这些呼吸腺粘液的产生和分泌。这一假设可以在体外通过定量RT-PCR进行验证，通过鉴定哮喘患者血液中的β - cm -7，发现在呼吸杯状细胞培养培养基中加入β - cm -7可以引起MUC5AC mRNA的增加。这种联系不一定是简单的因果关系，因为人必须喝A1牛奶，β - cm -7必须进入体循环，组织必须活跃地发炎。这些先决条件可以解释为什么只有一小部分呼吸道粘液分泌增加的人群发现，他们的许多症状，包括哮喘，在不吃乳制品的饮食中得到改善。2009爱思唯尔有限公司版权所有。
Excessive milk consumption has a long association with increased respiratory tract mucus production and asthma. Such an association cannot be explained using a conventional allergic paradigm and there is limited medical evidence showing causality. In the human colon, beta-casomorphin-7 (beta-CM-7), an exorphin derived from the breakdown of A1 milk, stimulates mucus production from gut MUC5AC glands. In the presence of inflammation similar mucus overproduction from respiratory tract MUC5AC glands characterises many respiratory tract diseases. beta-CM-7 from the blood stream could stimulate the production and secretion of mucus production from these respiratory glands. Such a hypothesis could be tested in vitro using quantitative RT-PCR to show that the addition of beta-CM-7 into an incubation medium of respiratory goblet cells elicits an increase in MUC5AC mRNA and by identifying beta-CM-7 in the blood of asthmatic patients. This association may not necessarily be simply cause and effect as the person has to be consuming A1 milk, beta-CM-7 must pass into the systemic circulation and the tissues have to be actively inflamed. These prerequisites could explain why only a subgroup of the population, who have increased respiratory tract mucus production, find that many of their symptoms, including asthma, improve on a dairy elimination diet. (C) 2009 Elsevier Ltd. All rights reserved.