Abuse in Childhood and Adolescence As a Predictor of Type 2 Diabetes in Adult Women
Abuse in Childhood and Adolescence As a Predictor of Type 2 Diabetes in Adult Women
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DOI：
10.1016/j.amepre.2010.09.007
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发表时间：
2010-12-01
影响因子：
5.5
通讯作者：
Wright, Rosalind J.
中科院分区：
文献类型：
--
作者：
Rich-Edwards, Janet W.;Spiegelman, Donna;Wright, Rosalind J.
背景资料：虽然虐待儿童与肥胖有关，但尚不清楚早期虐待是否会增加2型糖尿病的风险。目的：调查儿童和青少年虐待与成人糖尿病的关系。方法：使用比例风险模型研究2001年报告的终身虐待与1989年至2005年在护士健康研究II中的67，853名妇女患糖尿病的风险之间的关系。结果：54%的被调查者报告了儿童或青少年身体虐待，34%的被调查者报告了性虐待。模型根据年龄、种族、5岁时的体型、父母教育和糖尿病史进行调整。与未报告身体虐待的女性相比，轻度身体虐待的风险比（HR）为1.03（95% CI=0.91，1.17）;中度身体虐待为1.26（1.14，1.40）;重度身体虐待为1.54（1.34，1.77）。与未报告儿童期或青春期性虐待的女性相比，非自愿性接触的HR为1.16（95%CI =1.05，1.29）;强迫性行为的HR为1.34（1.13，1.59）;重复强迫性行为的HR为1.69（1.45，1.97）。成人BMI占60%（95%CI = 32%，87%）的儿童和青少年的身体虐待和64%（95%CI = 38%，91%）的协会性虐待与diabetes.Conclusions：中度至重度的身体和性虐待在儿童和青少年有剂量反应协会与成年女性2型糖尿病的风险。这种过度风险的部分原因是有早期虐待史的妇女的BMI较高。(Am J Prev Med 2010; 39（6）：529 - 536）（C）2010年美国预防医学杂志
Background: Although child abuse is associated with obesity, it is not known whether early abuse increases risk of type 2 diabetes.Purpose: To investigate associations of child and adolescent abuse with adult diabetes.Methods: Proportional hazards models were used to examine associations of lifetime abuse reported in 2001 with risk of diabetes from 1989 to 2005 among 67,853 women in the Nurses' Health Study II. Data were analyzed in 2009.Results: Child or teen physical abuse was reported by 54% and sexual abuse by 34% of participants. Models were adjusted for age, race, body type at age 5 years, and parental education and history of diabetes. Compared to women who reported no physical abuse, the hazards ratio (HR) was 1.03 (95% CI=0.91, 1.17) for mild physical abuse; 1.26 (1.14, 1.40) for moderate physical abuse; and 1.54 (1.34, 1.77) for severe physical abuse. Compared with women reporting no sexual abuse in childhood or adolescence, theHRwas 1.16 (95% CI=1.05, 1.29) for unwanted sexual touching; 1.34 (1.13, 1.59) for one episode of forced sexual activity; and 1.69 (1.45, 1.97) for repeated forced sex. Adult BMI accounted for 60% (95% CI=32%, 87%) of the association of child and adolescent physical abuse and 64% (95% CI=38%, 91%) of the association of sexual abuse with diabetes.Conclusions: Moderate to severe physical and sexual abuse in childhood and adolescence have dose-response associations with risk of type 2 diabetes among adult women. This excess risk is partially explained by the higher BMI of women with a history of early abuse. (Am J Prev Med 2010; 39(6): 529 -536) (C) 2010 American Journal of Preventive Medicine