Decreased CD1d level is associated with CD86 over-ex pression in B cells from systemic lupus erythematosus
Decreased CD1d level is associated with CD86 over-ex pression in B cells from systemic lupus erythematosus
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DOI：
10.1093/abbs/gmx011
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Yayi Hou
中科院分区：
文献类型：
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作者：
Fei Liu;Jianjian Ji;Xiujun Li;Xiaojing Li;Jingjing Xu;Huimin Yue;Shuli Zhao;Hongye Fan;Yayi Hou
The disorder of B cells is one of the hallmarks of systemic lupus erythematosus (SLE). The activa-tion state indicated by CD86 of B cells from SLE is well known, while the defect of regulatory B cells mediated by CD1d is also responsible for the process of SLE. In the present study, we.focused on the relationship between B cell activation mediated by CD86 and B cell regulatory func-tion mediated by CD1d. Our results showed that the level of CD1d in B cells was decreased during the early stages of B6.MRLlpr SLE mice and imiquimod-treated (IMQ-treated) mice, while the level.of CD86 was signi fi cantly increased at the late stage. Moreover, the expression of CD1d showed a significantly negative correlation with CD86 level in B cells from IMQ-treated mice ( r = −05741; P =0.0022), B6.MRLlpr mice (r = −0.7091; P = 0.0268), and SLE patients ( r = −0.4125; P = 0.0404). The.in vivo and in vitro experiments with splenocytes demonstrated that CD1d signaling pathway could inhibit toll-like receptor 7 (TLR7)-induced CD86 expression of B cells. Further studies showed that this relationship also affected antibody production. Thus, our results confi rmed the associ-ation of CD1d and CD86 levels in B cells from SLE, and demonstrated the importance to preserve the immunoregulatory function of B cells mediated by CD1d in the progression of SLE.
