Increased frequency of Interleukin-1β-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion
Increased frequency of Interleukin-1β-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion
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DOI：
10.1046/j.1528-1157.2003.43302.x
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发表时间：
2003-06-01
期刊：
影响因子：
5.6
通讯作者：
Nishimura, M
中科院分区：
文献类型：
--
作者：
Kanemoto, K;Kawasaki, J;Nishimura, M
目的：探讨IL-1β-511T等位基因在颞叶癫痫(TLE)和海马区硬化症(HS)患者中的高频率分布，特别是长期热性惊厥(PFC)对IL-1β基因分布的影响。方法：以磁共振(MR)有单侧HS的患者为研究对象(TLE+HS；n=66)。选择MRI基本正常或仅有异物组织的患者(TLE无HS；TLE-HS；n=)和有症状性定位相关癫痫但无TLE的患者(SLE；n=89)作为疾病对照。结果：IL-1β基因启动子区2511位点的单碱基多态性在TLE+HS患者和对照组之间存在显著差异。而TLE-HS患者与对照组、SLE患者与对照组之间无明显差异。此外，在TLE+HS组中，IL-1β-511T等位基因的频率随着热性惊厥的增加而增加[0.531不伴热性惊厥，0.633伴热性惊厥，0.686伴热性惊厥]。结论：PFC是IL-1β-511T等位基因频率的重要决定因素，因此PFC发病率的差异可以用来解释最近关于IL-1β-511和TLE+HS基因多态之间相互矛盾的结果。
Purpose: To confirm the high frequency of interleukin (IL)-1beta-511T allele occurrence in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS), with special attention given to the impact of prolonged febrile convulsions (PFCs) on IL-1beta genotype distribution.Methods: Patients with evidence of unilateral HS on magnetic resonance (MR) images were chosen as study subjects (TLE+HS; n = 66). Other patients with essentially normal MRI findings or only foreign tissue (TLE without HS; TLE-HS; n = 64), and those with symptomatic localization-related epilepsy but without TLE (SLE; n = 89) were selected as disease controls. A single base pair polymorphism at position 2511 in the promoter region of the IL-1beta gene was analyzed.Results: The distribution of IL-1beta-511 genotypes as well as allele frequency was significantly different between TLE+HS patients and controls. In contrast, no difference was found be-tween TLE-HS patients and controls or between SLE patients and controls. Further, in the group of patients with TLE+HS, the frequency of the IL-1beta-511T allele tended to increase as a function of febrile convulsions [0.531 without either PFC or simple febrile convulsion (SFC); 0.633 with SFC; 0.686 with PFC]. Although no statistically significant difference was noted between patients without PFC and the controls, a chi(2) analysis of allele distribution revealed a significant difference between those with PFC and the controls.Conclusions: PFC proved to be a potent determinant of IL-1beta-511T allele frequency; thus a discrepancy of PFC incidence should be considered an explanation of recent conflicting results regarding the association between the gene polymorphisms of IL-1beta-511 and TLE+HS.