Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5.
Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5.
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酵母 PDR3、PDR4、PDR7 和 PDR9 多效性（多个）耐药位点的突变会影响 ATP 结合盒转运蛋白编码基因 PDR5 的转录水平。
DOI：
10.1093/genetics/136.2.505
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发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
Golin,J
中科院分区：
文献类型：
--
作者：
Dexter,D;Moye-Rowley,WS;Wu,AL;Golin,J
酵母多效性（多药）耐药基因PDR5编码的产物与包括哺乳动物多药耐药家族在内的大量膜转运蛋白同源。在这项研究中，我们在染色体II上发现了四个影响PDR5转录物稳态水平的基因，以及之前发现的一个正调节基因PDR1。这些基因分别是PDR3、PDR4、PDR7和PDR9。我们还分析了PDR5和YAP1之间的相互作用。YAP1编码一个带有亮氨酸拉链基序的正调节因子，当过量产生时引起多效性耐药。yap1介导的多效性耐药不依赖于PDR5的存在，必须通过其他基因起作用。
The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 transcript in addition to a previously identified positive regulator, PDR1. The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes.