Plasma levels of apolipoproteins C-III, A-IV, and E are independently associated with stable atherosclerotic cardiovascular disease
Plasma levels of apolipoproteins C-III, A-IV, and E are independently associated with stable atherosclerotic cardiovascular disease
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DOI：
10.1016/j.atherosclerosis.2018.11.006
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发表时间：
2019-02-01
期刊：
影响因子：
5.3
通讯作者：
Ceglarek, Uta
中科院分区：
文献类型：
--
作者：
Dittrich, Julia;Beutner, Frank;Ceglarek, Uta
背景和目的：血脂异常是动脉粥样硬化性心血管疾病（ASCVD）的主要危险因素。载脂蛋白（apo）作为脂蛋白代谢的关键调节因子，被认为是血管危险因素。本研究旨在分析血浆主要成分与冠状动脉疾病（CAD）、外周动脉疾病（PAD）和颈动脉斑块（CAP）的关系，以阐明其在风险评估中的诊断潜力。apoA-I、apoA-II、apoA-IV、apoB-100、apoC-I、apoC-III、apoE，在Leipziger LIFE-心脏研究的病例-对照亚组（N = 911）中，通过LC-MS/MS在3 μ L EDTA-血浆中同时定量apoJ和apoJ。对人口统计学、临床协变量和血脂、心脏、炎症和肝脏标志物进行混杂因素分析。Apos与CAD，CAP和PAD在多变量回归model.Results：空腹和他汀类药物治疗显示载脂蛋白浓度最强的影响。观察到肌钙蛋白T和白细胞介素6与HDL相关的'A-I、A-II、A-IV和C-I呈负相关。在他汀类药物治疗下，B-100、C-1和E的浓度降低。在调整影响因素和相关血脂后，只有apoB-100（每一个SD的比值比[OR]，1.39; 95%置信区间[CI]，1.05-1.84）与CAD独立相关，而apoA-IV（OR，0.74; 95% CI 0.58-0.95）表明PAD。apoB-100（OR，1.55; 95% CI，1.18-2.04），apoC-III（OR，1.30; 95% CI，1.06-1.58），和apoE（OR，1.34; 95%CI，1.13-1.58）与CAP相关。富含甘油三酯的脂蛋白（TRL）相关的B-100、C-III和E独立地与稳定的ASCVD相关，为TRL在动脉粥样硬化形成中的潜在作用提供了进一步的证据。
Background and aims: Dyslipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). As key regulators of lipoprotein metabolism, apolipoproteins (apos) are discussed as vascular risk factors. This study aimed to analyze associations of major plasma apos with coronary artery disease (CAD), peripheral artery disease (PAD) and carotid artery plaque (CAP) to elucidate their diagnostic potential in risk assessment.Methods: ApoA-I, apoA-II, apoA-IV, apoB-100, apoC-I, apoC-III, apoE, and apoJ were simultaneously quantified in 3 mu L EDTA-plasma by LC-MS/MS in a case-control subgroup of the Leipziger LIFE-Heart Study (N = 911). Confounder analysis with demographic, clinical covariates and serum lipids, cardiac, inflammatory, and hepatic markers were performed. Apos were associated with CAD, CAP, and PAD in a multivariate regression model.Results: Fasting and statin therapy showed strongest effects on apo concentrations. Inverse correlations of HDL-related apos A-I, A-II, A-IV, and C-I were observed for troponin T and interleukin 6. Concentrations of apos A-II, B-100, C-I, and E were decreased under statin therapy. After adjustment for influencing factors and related lipids, only apoB-100 (odds ratio per one SD [OR], 1.39; 95% confidence interval [CI], 1.05-1.84) was independently associated with CAD while apoA-IV (OR, 0.74; 95% CI 0.58-0.95) indicated PAD. ApoB-100 (OR, 1.55; 95% CI, 1.18-2.04), apoC-III (OR, 1.30; 95% CI, 1.06-1.58), and apoE (OR, 1.34; 95% CI, 1.13-1.58) were associated with CAP.Conclusions: Triglyceride rich lipoproteins (TRLs) associated apos A-IV, B-100, C-III, and E are independently associated with stable ASCVD, providing further evidence for a potential role of TRLs in atherogenesis.