A single breath-hold multiecho T2*cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload
A single breath-hold multiecho T2*cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload
复制标题
DOI：
10.1002/jmri.10332
复制
发表时间：
2003-07-01
影响因子：
4.4
通讯作者：
Pennell, DJ
中科院分区：
文献类型：
--
作者：
Westwood, M;Anderson, LJ;Pennell, DJ
目的：应用梯度回波T2*MultiECHO技术评估组织铁浓度。我们比较了32例患者用建立的多屏气变量tR技术和一种新的多回声序列测量心脏t2*的结果。结果：两种方法在t2*和lt；20ms的异常范围内心肌t2*值有很好的一致性(平均差0.2msec，95%CI-1.3至0.9msec，r=0.97P<；0.0001)。方法间的变异系数为3.5%。使用MultiECHO序列的InterStudy重复性在异常T2*范围内的变异系数为2.3%，在所有T2*值上的变异系数为5.8%。肝脏T2*值的两种技术之间有很好的一致性。结论：使用单次屏气多ECHO序列可以可靠地定量心肌T2*。这项技术良好的重复性、速度和T1独立性使其具有更高的准确性、更快的患者吞吐量，并因此降低了成本(这在地中海贫血最普遍的发展中国家很重要)。
Purpose: To assess tissue iron concentration by the use of a gradient echo T2* multiecho technique.Materials and Methods. We compared;the results of measurements of heart T2* from 32 patients using the established multiple-breath-hold variable TR technique with,a new multiecho-sequence that acquires all images within a single breath-hold with constant TR.Results: There was good agreement of myocardial T2* values between both methods in the abnormal range of T2* < 20 msec (mean difference 0.2msec, 95% CI - 1.3 to 0.9 msec, r = 0.97, P < 0.0001). The coefficient of variability between the methods was 3.5%. The interstudy reproducibility using the:multiecho sequence had a variability coefficient of 2.3% in the abnormal T2* range and 5.8% over all T2* values There was good agreement between the techniques for the liver T2* valuesConclusions: The use of the single breath hold multiecho acquisition allowed reliable-quantification of, myocardial T2*. The good reproducibility speed and T1 independence of this technique allows greater accuracy faster, patient throughput, and; therefore reduced costs (which is important in developing countries where thalassemia is most prevalent).