Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro.
Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro.
复制标题
催乳素在体外抑制泪腺腺泡细胞的卡巴胆碱依赖性分泌。
DOI：
10.1007/978-1-4615-0717-8_31
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发表时间：
2002
影响因子：
--
通讯作者：
Mircheff,AustinK
中科院分区：
文献类型：
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作者：
Casbon,AmyJ;Warren,DwightW;Mircheff,AustinK
干燥性角结膜炎或干眼的特征是泪液分泌减少。由于这种疾病在女性中比男性更普遍，因此通常认为性激素与其病因有关。性类固醇和性二态肽激素催乳素一直在研究中。有几份报告揭示了高水平的催乳素和泪腺功能之间的负相关。对垂体切除大鼠1和人类受试者的研究表明，循环催乳素（PRL）水平过高会损害泪液分泌。2催乳素水平在雌性中高于雄性，并且在妊娠期间升高，这与泪液功能下降雅阁（Schechter等人，未公布的数据）。催乳素似乎也与自身免疫性疾病如干燥综合征密切相关。大分子催乳素（60kD）在干燥综合征患者的唾液腺上皮细胞中过度表达，3 46%的原发性干燥综合征患者存在高催乳素血症。4此外，催乳素和催乳素受体均在泪腺中合成，5人泪液中检测到PRL，6提示催乳素起内分泌、旁分泌、以及自分泌在泪腺功能和眼表维护中的作用。
Keratoconjunctivitis sicca, or dry eye, is characterized by decreased lacrimal fluid secretion. Since this disease is more prevalent in females than males, it has generally been assumed that the sex hormones are involved in its etiology. The sex steroids and the sexually dimorphic peptide hormone prolactin have been under investigation. There have been several reports that reveal a negative correlation between high levels of prolactin and lacrimal gland function. Studies with hypophysectomized rats1and with human subjects suggest that excessive levels of circulating prolactin (PRL) impair lacrimal secretion.2Prolactin levels are higher in females than males and rise during pregnancy, in accord with decreased lacrimal function (Schechter et al., unpublished data). Prolactin also seems to be closely linked to autoimmune diseases such as Sjögren’s Syndrome. Big prolactin, 60kD, is found to be overexpressed in salivary glandular epithelial cells of Sjögren’s syndrome patients,3and hyperprolactinemia is found in 46% of patients with primary Sjögren’s syndrome.4In addition, both prolactin and prolactin receptors are synthesized in the lacrimal gland,5and PRL has been detected in human tears,6suggesting that prolactin plays endocrine, paracrine, and autocrine roles in lacrimal gland function and maintenance of the ocular surface.