Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan
Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan
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DOI：
10.1093/sleep/27.7.1255
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发表时间：
2004-11-01
期刊：
影响因子：
5.6
通讯作者：
Vitiello, MV
中科院分区：
文献类型：
--
作者：
Ohayon, MM;Carskadon, MA;Vitiello, MV
目的：本研究的目的是确定与年龄有关的变化，客观记录的睡眠模式在整个人类寿命的健康个体，并澄清是否睡眠潜伏期和百分比的阶段1，阶段2，快速眼动（REM）睡眠显着改变与age.Design：回顾文献的文章发表在1960年和2003年之间的同行评议的期刊和荟萃分析。65项研究，代表3,577名年龄在5岁至102岁的受试者.测量：纳入本荟萃分析的研究报告符合以下标准：（1）包括年龄在5岁或以上的非临床参与者;（2）包括通过“整夜”多导睡眠描记器或活动描记器对睡眠潜伏期、睡眠效率、总睡眠时间、第1阶段睡眠、第2阶段睡眠、慢波睡眠，快速眼动睡眠，快速眼动潜伏期，或分钟清醒后入睡;（3）包括数字表示的数据;（4）发表在1960年和2003年之间的同行评审journals.Results：在儿童和青少年，总睡眠时间随着年龄的增长，只有在上学的日子进行的研究。慢波睡眠百分比与年龄呈显著负相关。第2阶段和快速眼动睡眠的时间随年龄的增长而显著变化。在成年人中，总睡眠时间、睡眠效率、慢波睡眠百分比、REM睡眠百分比和REM潜伏期均随年龄显著降低，而睡眠潜伏期、第1阶段睡眠百分比、第2阶段睡眠百分比和入睡后觉醒均随年龄显著增加。然而，只有睡眠效率在60岁后继续显著下降。的影响大小的幅度指出改变取决于是否研究参与者进行筛选精神障碍，器质性疾病，使用药物或酒精，阻塞性睡眠呼吸暂停综合征，或其他sleep disorders.Conclusions：在成年人中，似乎睡眠潜伏期，阶段1和阶段2的百分比显着增加，而REM睡眠的百分比下降。然而，受试者筛选的质量极大地改变了不同睡眠参数的效应量，减少甚至掩盖了年龄与不同睡眠参数的相关性。在学龄儿童、青少年和中年人中，研究睡眠参数随年龄变化的研究很少。也有很少的研究检查种族对多导睡眠参数的影响。
Objectives: The purposes of this study were to identify age-related changes in objectively recorded sleep patterns across the human life span in healthy individuals and to clarify whether sleep latency and percentages of stage 1, stage 2, and rapid eye movement (REM) sleep significantly change with age.Design: Review of literature of articles published between 1960 and 2003 in peer-reviewed journals and meta-analysis.Participants: 65 studies representing 3,577 subjects aged 5 years to 102 years.Measurement: The research reports included in this meta-analysis met the following criteria: (1) included nonclinical participants aged 5 years or older; (2) included measures of sleep characteristics by "all night" polysomnography or actigraphy on sleep latency, sleep efficiency, total sleep time, stage 1 sleep, stage 2 sleep, slow-wave sleep, REM sleep, REM latency, or minutes awake after sleep onset; (3) included numeric presentation of the data; and (4) were published between 1960 and 2003 in peer-reviewed journals.Results: In children and adolescents, total sleep time decreased with age only in studies performed on school days. Percentage of slow-wave sleep was significantly negatively correlated with age. Percentages of stage 2 and REM sleep significantly changed with age. In adults, total sleep time, sleep efficiency, percentage of slow-wave sleep, percentage of REM sleep, and REM latency all significantly decreased with age, while sleep latency, percentage of stage 1 sleep, percentage of stage 2 sleep, and wake after sleep onset significantly increased with age. However, only sleep efficiency continued to significantly decrease after 60 years of age. The magnitudes of the effect sizes noted changed depending on whether or not studied participants were screened for mental disorders, organic diseases, use of drug or alcohol, obstructive sleep apnea syndrome, or other sleep disorders.Conclusions: In adults, it appeared that sleep latency, percentages of stage 1 and stage 2 significantly increased with age while percentage of REM sleep decreased. However, effect sizes for the different sleep parameters were greatly modified by the quality of subject screening, diminishing or even masking age associations with different sleep parameters. The number of studies that examined the evolution of sleep parameters with age are scant among school-aged children, adolescents, and middle-aged adults. There are also very few studies that examined the effect of race on polysomnographic sleep parameters.