Combined diet and exercise intervention reverses the metabolic syndrome in middle-aged males: results from the Oslo Diet and Exercise Study
Combined diet and exercise intervention reverses the metabolic syndrome in middle-aged males: results from the Oslo Diet and Exercise Study
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DOI：
10.1111/j.1600-0838.2006.00631.x
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发表时间：
2007-12-01
影响因子：
4.1
通讯作者：
Holme, I.
中科院分区：
文献类型：
--
作者：
Anderssen, S. A.;Carroll, S.;Holme, I.
我们检查了1年饮食和运动干预对中年男性国际糖尿病联合会（IDF）代谢综合征的单一和综合影响。该研究是一项随机、对照、2 x 2析因干预研究。参与者包括137名根据IDF标准患有代谢综合征的男性，年龄在40 - 49岁之间，随机分配到四个干预组：单独饮食（n = 34），单独运动（n = 34），饮食和运动相结合的干预（n = 43）或对照组（n = 26）。主要的结局指标是根据IDF标准（2005）定义的代谢综合征。饮食与运动相结合组干预1年后代谢综合征发生率为32.6%（P <0.0001）。在仅饮食组中，22名参与者（64.7%）（P = 0.023 vs对照组）和仅运动组中26名参与者（76.5%）（P = 0.23 vs对照组）在干预后患有代谢综合征。采用析因设计，饮食干预和运动干预对代谢综合征的缓解均有显著影响（P <0.005）。与对照组相比，运动和饮食干预1年后降低了代谢综合征的患病率。然而，在治疗代谢综合征方面，饮食和运动相结合的干预措施比单独的饮食或运动更有效。
We examined the single and combined effects of a 1-year diet and exercise intervention on the International Diabetes Federation (IDF) metabolic syndrome among middle-aged males. The study was a randomized, controlled, 2 x 2 factorial intervention study. Participants included 137 men with metabolic syndrome according to the IDF criteria aged 40-49 years randomly allocated to four intervention groups: diet alone (n=34), exercise alone (n=34), the combination of the diet and exercise intervention (n=43) or control (n=26). The main outcome measure was metabolic syndrome as defined by IDF criteria (2005). In the combined diet and exercise group, 14 participants (32.6%) (P < 0.0001 as compared with control) had the metabolic syndrome after 1-year intervention. In the diet-only group, 22 participants (64.7%) (P=0.023 vs control) and in the exercise-only group 26 participants (76.5%) (P=0.23 vs control) had the metabolic syndrome following the intervention. Utilizing the factorial design, both dietary and exercise intervention had significant effects (P < 0.005) on the resolution of the metabolic syndrome. Both exercise and dietary intervention reduced metabolic syndrome prevalence compared with control after 1 year of intervention. However, the combined diet and exercise intervention was significantly more effective than diet or exercise alone in the treatment of the metabolic syndrome.