Dynamics of arginase gene evolution in metazoans
Dynamics of arginase gene evolution in metazoans
复制标题
后生动物精氨酸酶基因进化动态
DOI：
10.1080/07391102.2012.682207
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发表时间：
2012-01-01
影响因子：
4.4
通讯作者：
Shi, Feng
中科院分区：
文献类型：
--
作者：
Cao, Jun;Shi, Feng
本研究对后生动物中的辅酶A酶基因家族进行了全面的分析。在44个物种中共鉴定出126个丝氨酸蛋白酶基因。系统发育分析表明，该酶基因由四组组成。基因结构的保守性和差异性在不同的群体中存在。同线性也存在于多个物种间的远缘基因组中。适应性进化表明，虽然纯化选择可能是驱动酶进化的主要力量，但一些负责功能分化的关键位点可能处于正选择之下。总的来说，从我们的调查获得的数据有助于更好地了解的复杂性的酶基因家族的功能和进化，这个家庭在后生动物。
In the present study, a comprehensive analysis of the arginase gene family in metazoans was performed. A total of 126 arginase genes have been identified in 44 species. Phylogenetic analyses indicate that arginase genes consist of four groups. Conservative and divergent gene structures are found among the groups. The syntenies also exist in distantly related genomes among multiple species. Adaptive evolution shows that, while purifying selection may have been the main force driving the evolution of the arginases, some of critical sites responsible for the functional divergence may have been under positive selection. Overall, the data obtained from our investigation contribute to a better understanding of the complexity of the arginase gene family and of the function and evolution of this family in metazoans.