Deconvolution: A novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue
Deconvolution: A novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue
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DOI：
10.1161/01.cir.94.10.2633
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发表时间：
1996-11-15
期刊：
影响因子：
37.8
通讯作者：
Lesh, MD
中科院分区：
文献类型：
--
作者：
Ellis, WS;Eisenberg, SJ;Lesh, MD
背景电生理学中两个重要的信号处理应用是记录电描记图的组织基质的激活映射和表征。我们假设一种使用反卷积的新型信号处理方法比幅度、导数和手动激活时间估计更准确。我们进一步假设反卷积量化了形态学的变化，检测从心肌梗塞区域记录的电描记图。方法和结果为了确定激活时间估计的准确性，使用详细的计算机模型计算了 600 个单极电描记图，使用不同程度的耦合异质性来模拟梗塞。局部激活时间定义为最靠近电极的建模肌细胞中内向钠电流峰值的时间。计算反卷积、最小导数和最大幅度。两位经验丰富的电生理学家对计算机确定的激活时间视而不见，标记了他们对激活时间的估计。 F 检验比较了每种方法的激活时间估计的方差。为了评估去卷积检测梗塞的性能，记录了 10 只因结扎左冠状动脉前降支而梗塞的狗的 380 个单极电图。计算幅度、持续时间、拐点数量、峰值频率、带宽、最小导数和反卷积。通过曼-惠特尼秩和检验比较指标，并绘制受试者工作曲线。结论。反卷积估计局部激活时间比其他指标更准确（P
Background Two important signal processing applications in electrophysiology are activation mapping and characterization of the tissue substrate from which electrograms are recorded. We hypothesize that a novel signal-processing method that uses de convolution is more accurate than amplitude, derivative, and manual activation time estimates. We further hypothesize that deconvolution quantifies changes in morphology that detect electrograms recorded from regions of myocardial infarction.Methods and Results To determine the accuracy of activation time estimation, 600 unipolar electrograms were calculated with a detailed computer model using various degrees of coupling heterogeneity to model infarction. Local activation time was defined as the time of peak inward sodium current in the modeled myocyte closest to the electrode. Deconvolution, minimum derivative, and maximum amplitude were calculated. Two experienced electrophysiologists blinded to the computer-determined activation times marked their estimates of activation lime. F tests compared the variance of activation time estimation for each method. To evaluate the performance of deconvolution to detect infarction, 380 unipolar electrograms were recorded from 10 dogs with infarcts resulting from ligation of the left anterior descending coronary artery. The amplitude, duration, number of inflections, peak frequency, bandwidth, minimum derivative, and deconvolution were calculated. Metrics were compared by Mann-Whitney rank-sum tests, and receiver operating curves were plotted.Conclusions. Deconvolution estimated local activation time more accurately than the other metrics (P