Bio-Micromotor Tweezers for Noninvasive Bio-Cargo Delivery and Precise Therapy
Bio-Micromotor Tweezers for Noninvasive Bio-Cargo Delivery and Precise Therapy
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用于无创生物货物输送和精准治疗的生物微电机镊子
DOI：
10.1002/adfm.202111038
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发表时间：
2021-12-03
影响因子：
19
通讯作者：
Li, Baojun
中科院分区：
文献类型：
--
作者：
Pan, Ting;Shi, Yang;Li, Baojun
Active and targeted bio-cargo delivery by micromotors holds exciting prospects in biomedical applications. However, such delivery still faces great challenges when implemented in bio-microenvironments with minimal invasiveness, flexible controllability, and full biocompatibility. Here, a noncontact delivery platform based on bio-micromotor tweezers is reported, which fulfill these demands by using hydrodynamic forces to exert precision control over bio-cargos. The concept is based on two optically trapped living microalgae cells with intrinsic motility and biocompatibility: The rotating cells generate highly localized flow fields, which can trap and drive cargos of arbitrary material and shape along controllable trajectories in different biological media in a noncontact manner. The proposed strategy is effective for both biological cells and drugs with minimalized biological damages due to the absence of harmful and cumbersome loading/unloading steps of bio-cargos on micromotors. Importantly, it is further applied to realize targeted drug delivery into single cancer cell for precise therapy. Such bio-micromotor tweezers provide great potential for different biomedical applications such as, targeted drug/cell delivery, drug testing, accurate diagnosis, and precise therapy.
