Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer
Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer
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DOI：
10.1056/nejm199809173391201
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发表时间：
1998-09-17
影响因子：
158.5
通讯作者：
Gallo, MA
中科院分区：
文献类型：
--
作者：
DiPaola, RS;Zhang, HY;Gallo, MA
草药混合物是已证实的疗法的流行替代品。PC-SPES是一种市售的八种草药的组合，被用作前列腺癌的非雌激素治疗。由于其他草药在体外具有雌激素样作用，我们测试了PC-SPES在酵母和小鼠和前列腺癌的男性中的雌激素活性。方法我们测量了PC-SPES在酵母中的转录激活试验和小鼠中的生物测定的雌激素活性。我们评估的临床活性的PC-SPES在8例前列腺癌患者通过测量血清前列腺特异性抗原和睾酮浓度治疗期间和之后treatment.Results的补充酵母assays，1：200稀释的乙醇提取物的PC-SPES有雌激素活性类似的1 nM雌二醇，并在卵巢切除CD-1小鼠，草药混合物增加子宫重量大幅。在6例前列腺癌患者中，PC-SPES降低了血清睾酮浓度（P <0.05）。
Background Herbal mixtures are popular alternatives to demonstrated therapies. PC-SPES, a commercially available combination of eight herbs, is used as a nonestrogenic treatment for cancer of the prostate. Since other herbal medicines have estrogenic effects in vitro, we tested the estrogenic activity of PC-SPES in yeast and mice and in men with prostate cancer.Methods We measured the estrogenic activity of PC-SPES with transcriptional-activation assays in yeast and a biologic assay in mice. We assessed the clinical activity of PC-SPES in eight patients with hormone-sensitive prostate cancer by measuring serum prostate-specific antigen and testosterone concentrations during and after treatment.Results In complementary yeast assays, a 1:200 dilution of an ethanol extract of PC-SPES had estrogenic activity similar to that of 1 nM estradiol, and in ovariectomized CD-1 mice, the herbal mixture increased uterine weights substantially. In six of six men with prostate cancer, PC-SPES decreased serum testosterone concentrations (P