Protecting P-type plasma membrane H+-ATPases from ROS
Protecting P-type plasma membrane H+-ATPases from ROS
复制标题
保护 P 型质膜 H -ATP 酶免受 ROS 的影响
DOI：
10.1042/bcj20210109
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发表时间：
2021
影响因子：
4.1
通讯作者：
Jez, Joseph M.
中科院分区：
文献类型：
--
作者：
Stainbrook, Sarah C.;Jez, Joseph M.
P型ATP酶是所有生命界中普遍存在的转运蛋白。这些蛋白质共有一个共同的机制，涉及一个不变的天冬氨酸的磷酸化，以促进底物从质子到磷脂跨细胞膜的运动。在这一期的《生物化学杂志》上，韦勒等人在P型质膜H+-ATP酶的功能关键天冬氨酸附近鉴定了一个保守的半胱氨酸，该半胱氨酸保护蛋白质免受活性氧的侵害。
P-type ATPase are ubiquitous transport proteins across all kingdoms of life. These proteins share a common mechanism involving phosphorylation of an invariant aspartate to facilitate movement of substrates from protons to phospholipids across cellular membranes. In this issue of theBiochemical Journal, Welle et al. identify a conserved cysteine near the functionally critical aspartate of P-type plasma membrane H+-ATPases that protects the protein from reactive oxygen species.