GENERAL AND DRAMATIC GLIAL REACTION IN ALZHEIMER BRAINS
GENERAL AND DRAMATIC GLIAL REACTION IN ALZHEIMER BRAINS
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DOI：
10.1212/wnl.40.1.33
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发表时间：
1990-01-01
期刊：
影响因子：
9.9
通讯作者：
DELACOURTE, A
中科院分区：
文献类型：
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作者：
DELACOURTE, A
我们使用免疫印迹技术和抗胶质细胞酸性蛋白（GFAP）定量分析了阿尔茨海默病（AD）患者不同脑区的未分级匀浆中的胶质细胞酸性蛋白（GFAP）。GFAP的量显著高于对照组和其他神经退行性疾病的大脑（平均11倍），即使在通常无AD病变的大脑区域，如尾状核，丘脑，小脑或脑干。GFAP的这种急剧增加不仅仅反映了通常在神经纤维缠结和老年斑附近观察到的星形胶质细胞胶质增生，而是更可能代表了整个大脑中对应于GFAP过度产生或积累的星形胶质细胞反应。这种增加的意义尚不清楚，但它可能是AD发病机制中的关键因素。
We quantified glial fibrillary acidic protein (GFAP) using immunoblot techniques and anti-GFAP, in unfractionated homogenates of different brain regions from Alzheimer''s disease (AD) patients. The amount of GFAP was significantly higher than in brains from controls and other neurodegenerative disorders (mean of 11 times), even in brain regions usually free of AD lesions such as caudate nucleus, thalamus, cerebellum, or brainstem. This dramatic increase of GFAP is not simply reflective of the astrocytic gliosis usually observed near the neurofibrillary tangles and senile plaques but more likely represents an astrocytic reaction in the whole brain corresponding to an overproduction or an accumulation of GFAP. The significance of such an increase is unknown, but it might be a key element in the pathogenesis of AD.