Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.
Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.
复制标题
扭曲和熨烫：线粒体 DNA 损伤导致阿霉素心脏毒性。
DOI：
10.1158/1078-0432.ccr-14-0821
复制
发表时间：
2014-09-15
期刊：
影响因子：
--
通讯作者：
Nitiss JL
中科院分区：
文献类型：
--
作者：
Nitiss KC;Nitiss JL
蒽环类药物是具有多种细胞毒性机制的临床活性药物。蒽环类药物的心脏毒性限制了这些药物的治疗潜力，但导致心脏毒性的机制仍然存在争议。缺乏线粒体拓扑异构酶I的转基因小鼠对阿霉素心脏毒性过敏，这为线粒体DNA损伤引起的心脏毒性提供了支持。
Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA.