Facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular bis-heterocyclizations
Facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular bis-heterocyclizations
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DOI：
10.1021/jo702067z
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发表时间：
2008-01-04
影响因子：
3.6
通讯作者：
Kurth, Mark J.
中科院分区：
文献类型：
--
作者：
Butler, Jeffrey D.;Solano, Danielle A.;Kurth, Mark J.
[图表]母体5 H-吲唑并[3，2-B]苯并[d]-1，3-恶嗪杂环以及一系列新的类似物已经利用两个随后的分子内杂环化反应在一锅中合成。加入了各种多样性基团以探索该反应的范围，并为生物筛选提供了许多新的化合物。
[GRAPHICS]The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.