New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart.
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart.
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DOI：
10.1155/2014/210934
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发表时间：
2014
影响因子：
--
通讯作者：
Sadoshima J
中科院分区：
文献类型：
--
作者：
Ikeda Y;Sciarretta S;Nagarajan N;Rubattu S;Volpe M;Frati G;Sadoshima J
心脏对衰老过程高度敏感。在老年人，心脏往往会变得肥大和纤维化。僵硬增加，随之而来的是收缩和舒张期功能障碍。衰老也会影响心脏对压力的反应。在分子水平上，衰老过程与受损蛋白质和细胞器的积累有关，部分原因是蛋白质质量控制系统的缺陷。线粒体功能障碍和异常堆积是衰老过程中的一个重要的病理生理特征，它与活性氧的过度产生有关。线粒体融合和分裂以及线粒体自噬是维持线粒体功能和维持能量产生的重要机制。特别是，线粒体分裂允许有选择地分离受损的线粒体，然后通过自噬消除这些线粒体。不幸的是，最近的证据表明，随着时间的推移，线粒体动力学和自噬逐渐受损，导致衰老过程。这表明，恢复这些机制可以延缓器官衰老，预防与年龄相关的心脏病。在这里，我们讨论目前对线粒体动力学、有丝分裂、氧化应激和衰老之间密切关系的理解，尤其是心脏。
The heart is highly sensitive to the aging process. In the elderly, the heart tends to become hypertrophic and fibrotic. Stiffness increases with ensuing systolic and diastolic dysfunction. Aging also affects the cardiac response to stress. At the molecular level, the aging process is associated with accumulation of damaged proteins and organelles, partially due to defects in protein quality control systems. The accumulation of dysfunctional and abnormal mitochondria is an important pathophysiological feature of the aging process, which is associated with excessive production of reactive oxygen species. Mitochondrial fusion and fission and mitochondrial autophagy are crucial mechanisms for maintaining mitochondrial function and preserving energy production. In particular, mitochondrial fission allows for selective segregation of damaged mitochondria, which are afterward eliminated by autophagy. Unfortunately, recent evidence indicates that mitochondrial dynamics and autophagy are progressively impaired over time, contributing to the aging process. This suggests that restoration of these mechanisms could delay organ senescence and prevent age-associated cardiac diseases. Here, we discuss the current understanding of the close relationship between mitochondrial dynamics, mitophagy, oxidative stress, and aging, with a particular focus on the heart.
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影响因子：
20.1
作者：
Dai DF;Rabinovitch PS;Ungvari Z
通讯作者：
Ungvari Z
影响因子：
7.8
作者：
Dai DF;Karunadharma PP;Chiao YA;Basisty N;Crispin D;Hsieh EJ;Chen T;Gu H;Djukovic D;Raftery D;Beyer RP;MacCoss MJ;Rabinovitch PS
通讯作者：
Rabinovitch PS
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
20.1
作者：
Bhandari P;Song M;Chen Y;Burelle Y;Dorn GW 2nd
通讯作者：
Dorn GW 2nd
Parkin对泛素 - 蛋白酶体系统的广泛激活对于线粒体至关重要。
影响因子：
3.5
作者：
Chan NC;Salazar AM;Pham AH;Sweredoski MJ;Kolawa NJ;Graham RL;Hess S;Chan DC
通讯作者：
Chan DC