Parametric features of habituation of swim cycle number in the marine mollusc Tritonia diomedea
Parametric features of habituation of swim cycle number in the marine mollusc Tritonia diomedea
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DOI：
10.1006/nlme.1996.0015
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发表时间：
1996-03-01
影响因子：
2.7
通讯作者：
Getting, PA
中科院分区：
文献类型：
--
作者：
Frost, WN;Brown, GD;Getting, PA
当被反复引诱时，海洋软体动物Tritonia diomedea的振荡逃逸游泳经历了每次游泳的周期数的习惯化。因为这一行为的神经回路被很好地理解了，所以对三叉神经性习惯化的细胞分析是可行的。由于这样的研究最终必须将细胞相关与行为改变联系起来，我们试图增加我们对Tritonia中周期数习惯化的参数特征的理解。使用不同的试验间隔、重复的训练课程和不同的刺激位置来比较习惯化。习惯化的刺激部位泛化被证明，提示习惯化下的至少一个可塑性部位位于感觉神经元的突触后以进行反应。没有从高于零的基线反应水平获得去习惯化。一种分离的脑制剂被测试为一种潜在的简化系统，用于习惯化机制的细胞研究。反复刺激含有感觉传入突起的神经，导致游泳运动程序循环次数逐渐减少，其比率与行为中看到的相似。综上所述，这些发现：(1)建立了一套可由生理学研究解释的周期数习服的参数特征；(2)表明习惯化的至少一个回路修饰位于回路中间神经元之间；(3)表明分离的脑准备可作为一种有用的神经模拟，用于研究Tritonia的循环数习服的细胞机制。(C)1996年学术出版社。
When repeatedly elicited, the oscillatory escape swim of the marine mollusc Tritonia diomedea undergoes habituation of the number of cycles per swim. Because the neural circuit for this behavior is reasonably well understood, a cellular analysis of habituation in Tritonia is feasible. Since such a study must ultimately relate cellular correlates to behavioral modifications, we have sought to increase our understanding of the parametric features of cycle number habituation in Tritonia. Habituation was compared when using different intertrial intervals, repeated training sessions, and different stimulus locations. Stimulus site generalization of habituation was demonstrated, suggesting that at least one site of plasticity underlying habituation is located postsynaptic to the sensory neurons for the response. Dishabituation from an above-zero baseline response level was not obtained. An isolated brain preparation was tested as a potential simplified system for cellular studies of habituation mechanisms. Repeated stimulation of a nerve containing sensory afferent processes resulted in a progressive reduction of swim motor program cycle number, with a rate similar to that seen in the behavior. Together, these findings: (1) establish a set of parametric features of cycle number habituation to be explained by physiological studies; (2) suggest that at least one circuit modification underlying the habituation is located among the circuit interneurons; and (3) indicate that the isolated brain preparation may serve as a useful neural analogue for studies of the cellular mechanisms of cycle number habituation in Tritonia. (C) 1996 Academic Press, Inc.